tgf-beta

Dysfunction of Primary Cilium in Huntington’s Disease: How Mutant Huntingtin Disrupts This Cellular Signaling Hub Churkina, Aleksandra S; Shakhov, Anton S; Alieva, Irina B Primary cilia are solitary, antenna-like organelles that project from the surface of most vertebrate cells. They consist of...

B cell deficiency limits exercise capacity by remodeling liver glutamate metabolism B cells are an essential component of humoral immunity, and B cell depletion therapies have clinically succeeded in eliminating cancerous B cells and treating autoimmune diseases. Here, we report an...

Choroid plexus inflammation in bipolar disorder Inflammation has emerged as a prominent feature of bipolar disorder (BD) pathophysiology, drawing attention to brain barriers known to regulate immune-brain interactions. While perturbation of the blood–brain barrier has been reported in BD, the...

https://www.nature.com/articles/s41590-025-02399-x Authors: Annukka A. R. Antar, Elizabeth C. Pasetes, Kay’La M. Z. Brennon & Andrea L. Cox Distinct monocyte gene expression programs were identified in people with long COVID after mild-to-moderate COVID-19 versus severe acute COVID-19...

Abstract: MicroRNAs (miRs) are involved in regulating various biological processes and may contribute to the pathophysiology of fibromyalgia syndrome (FMS). In order to explore correlations with clinical characteristics and to identify specific clusters, we performed plasma miR sequencing in 113...

https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(25)00522-1 Highlights • Female long COVID (LC) patients show heightened immune activation and inflammation • Disrupted sex hormone levels differ between male and female LC patients • Neuroinflammatory gene signatures may explain...

Blood diagnostic biomarkers for neurologic manifestations of long COVID BACKGROUND SARS-CoV-2 responsible for COVID-19 caused a global pandemic, with billions of infections, millions of deaths and ongoing manifestations post COVID-19. “Long Covid”, a Post-Acute Sequelae of COVID-19 (PASC), is...

scRNA-seq reveals persistent aberrant differentiation of nasal epithelium driven by TNFα and TGFβ in post-COVID syndrome Post-COVID syndrome (PCS) affects approximately 3-17% of individuals following acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and poses a potential global...

Erythrocytes as a Source of Exerkines Exercise activates many metabolic and signaling pathways in skeletal muscle and other tissues and cells, causing numerous systemic beneficial metabolic effects. Traditionally recognized for their principal role in oxygen (O2) transport, erythrocytes have...

Identification of novel genes regulated by IL-12, IL-4, or TGF-beta during the early polarization of CD4+ lymphocytes Riikka Lund, Tero Aittokallio, Olli Nevalainen, Riitta Lahesmaa Abstract Th1 and Th2 cells arise from a common precursor cell in response to triggering through the TCR and...

Circulating cell-free RNA signatures for the characterization and diagnosis of myalgic encephalomyelitis/chronic fatigue syndrome Anne E. Gardella, Daniel Eweis-LaBolle, Conor J. Loy, Emma D. Belcher, Joan S. Lenz, Carl J. Franconi, Sally Y. Scofield, Andrew Grimson, Maureen R. Hanson, Iwijn De...

Increased neutrophil apoptosis in chronic fatigue syndrome G Kennedy; V Spence; C Underwood; J J F Belch BACKGROUND / AIMS Many patients with chronic fatigue syndrome (CFS) have symptoms that are consistent with an underlying viral or toxic illness. Because increased neutrophil apoptosis occurs...

Wuhan strain of SARS-CoV-2 triggers activation of immune evasion machinery similar to the one operated by cancer cells Abooali, Maryam ; Yasinska, Inna M. ; Thapa, Gauri ; Lei, Xi ; da Costa, Kelly A. S. ; Schlichtner, Stephanie ; Berger, Steffen M. ; Fasler-Kan, Elizaveta ; Temperton, Nigel J...

TGF-β inhibitor SB431542 suppresses coronavirus replication through multistep inhibition Assim Verma; Garvit Kumar; Nitin Khandelwal; Benjamin E Mayer; Jitender Rathee; Yogesh Chander; Alka Nokhwal; Shweta Dhanda; Ram Kumar; Himanshu Kamboj; Riyesh Thachamvally; Shalini Sharma; Naveen Kumar The...

Cytokine signature associated with disease severity in chronic fatigue syndrome patients Jose G Montoya, Tyson H Holmes, Jill N Anderson, Holden T Maecker, Yael Rosenberg-Hasson, Ian J Valencia, Lily Chu, Jarred W Younger, Cristina M Tato, Mark M Davis Published: July 31, 2017 [Line breaks...

Abstract In a subset of children and adolescents, SARS-CoV-2 infection induces a severe acute hyperinflammatory shock1 termed multisystem inflammatory syndrome in children (MIS-C) at four to eight weeks after infection. MIS-C is characterized by a specific T cell expansion2 and systemic...

Now published, see post #11. ------------------------------------- Integrative Multi-Omics Framework for Causal Gene Discovery in Long COVID Thuc Duy Le, Sindy Licette Pinero, Xiaomei Li, Lin Liu, Jiuyong Li, Sang Hong Lee, Marnie Winter, Thin Nguyen, Junpeng Zhang Background Long COVID, or...

Highlights Mononuclear cells are primary drivers of the exercise response in skeletal muscle • Release of histamine from skeletal muscle during exercise from mast cells • Histamine receptor antagonists impair post-exercise muscle glycogen resynthesis • Exercise-induced transcriptional...

Now published, see post #5 ------------------ Abstract: Background: Epstein-Barr virus (EBV) infection is a known trigger and risk factor for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and post-COVID syndrome (PCS). In previous studies, we found enhanced IgG reactivity to EBV...

Vascular fibrosis and extracellular matrix remodelling in post-COVID 19 conditions Kamdar; Sykes; Thomson; Mangion; Ang; Lee; Van Agtmael; Berry Causal associations between viral infections and acute myocardial injury are not fully understood, with mechanisms potentially involving direct...