viral persistence

Identification of SARS-CoV-2 Persistent Infectious Epithelial Syndrome (SPIES) as a Novel Disease Entity using Clinical, Histologic, and RNA Programmatic Data Thomas Wallach, Ahmed Soliman, John Agboola, Shagun Sharma, Lais Araujo Coelho, Meredith Pittman, Christos Chatzinakos, Sergios-Orestis...

Abstract Introduction: The relationship between SARS-CoV-2 viral dynamics during acute infection and the development of long COVID is largely unknown. Methods: A total of 7361 asymptomatic community-dwelling people enrolled in the Test Us at Home parent study between October 2021 and February...

Assessment of the Impact of RNase in Patients With Severe Fatigue Related to Post-Acute Sequelae of SARS-CoV-2 Infection PASC: A Randomized Phase 2 Trial of RSLV-132 Andrews, James S; Boonyaratanakornkit, Jim B; Krusinska, Eva; Allen, Suzanne; Posada, James A BACKGROUND Severe acute respiratory...

Hi I wanted to create a thread on the organisation long covid action project to keep up with what they are doing. (A lot of which worries me.) This organisation says and claims as fact that long covid is a single disease caused by viral persistance. From their front page: Long Covid is a...

Clearance of gut mucosal SARS-CoV-2 antigens and post-acute COVID-19 after two years in patients with inflammatory bowel disease Andreas Zollner; Robert Koch; Almina Jukic; Alexandra Pfister; Moritz Meyer; Nikolaus Wick; Georg Wick; Annika Rössler; Janine Kimpel; Timon E. Adolph; Herbert Tilg...

Abstract Purpose This multicenter, prospective study is designed to investigate whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is present in the Middle Ear Effusion (MEE) of patients developing Otitis Media with Effusion (OME) subsequent to an Omicron infection. The...

Restrained memory CD8+ T cell responses favors viral persistence and elevated IgG responses in patients with severe Long COVID. Lucie Rodriguez; Ziyang Tan; Lakshmi Kanth Tadepally; Jun Wang; Hugo Barcenilla; Zoe Swank; Fanglei Zuo; Hassan Abolhassani; Ana Jimena Pavlovitch-Bedzyk; Chunlin Wang...

Published as a preprint. See post #7 And now published in final form - link here ****** This is an abstract from the Demystifying Long COVID International Conference 2023, converted from an image on Twitter, so it might be slightly wonky, but it looks intriguing. Blood Transcriptomics Reveal...

The neurobiology of SARS-CoV-2 infection Meinhardt, Jenny; Streit, Simon; Dittmayer, Carsten; Manitius, Regina v.; Radbruch, Helena; Heppner, Frank L. Worldwide, over 694 million people have been infected with SARS-CoV-2, with an estimated 55–60% of those infected developing COVID-19. Since the...

SARS-CoV-2 viral persistence in lung alveolar macrophages is controlled by IFN-γ and NK cells Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA generally becomes undetectable in upper airways after a few days or weeks postinfection. Here we used a model of viral...

SARS-CoV-2 spike antigen-specific B cell and antibody responses in pre-vaccination period COVID-19 convalescent males and females with or without post-covid condition Limoges, Marc-André; Quenum, Akouavi Julite Irmine; Chowdhury, Mohammad Mobarak Hussain; Rexhepi, Fjolla; Namvarpour, Mozhdeh...

SARS-CoV-2 infection triggers pro-atherogenic inflammatory responses in human coronary vessels Abstract Patients with coronavirus disease 2019 (COVID-19) present increased risk for ischemic cardiovascular complications up to 1 year after infection. Although the systemic inflammatory response to...

Tonsils are major sites of persistence of SARS-CoV-2 in children ABSTRACT In the present study, we show that SARS-CoV-2 can infect palatine tonsils, adenoids, and secretions in children without symptoms of COVID-19, with no history of recent upper airway infection. We studied 48 children...

Abstract Two coronaviruses were isolated from brain material obtained at autopsy from two multiple sclerosis patients. The viruses were neutralized by serum and spinal fluid from these patients. Although most of the population have antibody to these virus isolates, multiple sclerosis patients...

SARS-CoV-2 reservoir in post-acute sequelae of COVID-19 (PASC) Abstract Millions of people are suffering from Long COVID or post-acute sequelae of COVID-19 (PASC). Several biological factors have emerged as potential drivers of PASC pathology. Some individuals with PASC may not fully clear the...

A multicenter virome analysis of blood, feces, and saliva in myalgic encephalomyelitis/chronic fatigue syndrome Thomas Briese; Rafal Tokarz; Lucinda Bateman; Xiaoyu Che; Cheng Guo; Komal Jain; Vishal Kapoor; Susan Levine; Mady Hornig; Alexandra Oleynik; Phenix-Lan Quan; Wai H. Wong; Brent L...

Now published - link here ****** Preprint Multimodal Molecular Imaging Reveals Tissue-Based T Cell Activation and Viral RNA Persistence for Up to Two Years Following COVID-19 Michael J Peluso; Dylan M Ryder; Robert Flavell; Yingbing Wang; Jelena Levi; Brian H LaFranchi; Tyler-Marie M Deveau...

Long-Term Dysfunction of Taste Papillae in SARS-CoV-2 BACKGROUND We sought to determine whether ongoing taste disturbance in the postacute sequelae of coronavirus disease 2019 period is associated with persistent virus in primary taste tissue. METHODS We performed fungiform papillae biopsies...

IIMEC15 08 Professor Maureen Hanson 15th Invest in ME Research International ME Conference 2023 29 minutes Terrific presentation from Professor Maureen Hanson including some unpublished work I think we are getting close to some real answers - exhausted t-cells, abnormal classical monocytes...

Lindsey B. Crawford, a ,* Nicole L. Diggins, a Patrizia Caposio, a and Meaghan H. Hancock a Abstract Human cytomegalovirus (HCMV) is a highly prevalent beta-herpesvirus and a significant cause of morbidity and mortality following hematopoietic and solid organ transplant, as well as the leading...