viral persistence

https://www.bmj.com/content/382/bmj.p1156 Feature Covid Unanswered Questions Where do viruses hide in the human body? BMJ 2023; 382 doi: https://doi.org/10.1136/bmj.p1156 (Published 04 July 2023)Cite this as: BMJ 2023;382:p1156 Andy Extance, freelance journalist The question of how...

imPROving Quality of LIFe In the Long COVID Patient (PROLIFIC) https://clinicaltrials.gov/ct2/show/NCT05823896 Petter Brodin Karolinska Institutet, Sweden "Brief Summary: The purpose of this study is to investigate the efficacy of orally administered nirmatrelvir/ritonavir compared with...

Neurologic sequelae of COVID-19 are determined by immunologic imprinting from previous coronaviruses Spatola, Marianna; Nziza, Nadège; Jung, Wonyeong; Deng, Yixiang; Yuan, Dansu; Dinoto, Alessandro; Bozzetti, Silvia; Chiodega, Vanessa; Ferrari, Sergio; Lauffenburger, Douglas A; Mariotto, Sara...

Viral persistence, reactivation, and mechanisms of long COVID Benjamin Chen; Boris Julg; Sindhu Mohandas; Steven B Bradfute; RECOVER Mechanistic Pathways Task Force; Zaki A Sherif; Christian R Gomez; Thomas J Connors; Timothy J Henrich; W Brian Reeves; K Coombs; C Kim; Pras Jagannathan...

Highlights• Cellular stress provokes activation of viral replication in an RNA virus model The viral replication factories are liquid-like condensates that coarsen under stress Stress-triggered IDR phosphorylation stabilizes the viral replication machinery In-cell nucleocapsid structures reveal...

SARS-CoV-2 Spike Protein Accumulation in the Skull-Meninges-Brain Axis: Potential Implications for Long-Term Neurological Complications in post-COVID-19 Zhouyi Rong; Hongcheng Mai; Saketh Kapoor; Victor Puelles; Jan Czogalla; Julia Schaedler; Jessica Vering; Claire Delbridge; Hanno Steinke...

Key Points Question Is treatment with nirmatrelvir in the acute phase of SARS-CoV-2 infection associated with a lower risk of post–COVID-19 condition (PCC)? Findings In this cohort study of 281 793 people with SARS-CoV-2 infection who had at least 1 risk factor for progression to severe...

https://www.frontiersin.org/articles/10.3389/fmed.2022.1003103/full Introduction: Long COVID, or post-acute sequelae of SARS-CoV-2 infection (PASC) in ∼30% of all infected individuals. Here, we present a case of PASC in a patient with rheumatoid arthritis characterized by viral persistence in...

High number of SARS-CoV-2 persistent infections uncovered through genetic analysis of samples from a large community-based surveillance study Multiple researchers from Universities of Oxford and Northumbria, Office for National Statistics, Wellcome Sanger Institute COVID-19 Surveillance Team...

Persistent alveolar type 2 dysfunction and lung structural derangement in post-acute COVID-19 Andre Figueiredo Rendeiro, Hiranmayi Ravichandran, Junbum Kim, Alain Borczuk, Olivier Elemento, Robert Edward Schwartz SARS-CoV-2 infection can manifest as a wide range of respiratory and systemic...

Persistent Presence of Spike protein and Viral RNA in the Circulation of Individuals with Post-Acute Sequelae of COVID-19 Vaughn Craddock, Aatish Mahajan, Balaji Krishnamachary, Leslie Spikes, PrabhakarChalise, Navneet Kaur Dhillon SARS-CoV-2, the causative agent of COVID-19 disease has...

PolyBio Research Foundation Receives $1.3 Million Gift to Advance the study of SARS-CoV-2 Viral Persistence in patients with LongCovid https://polybio.org/portfolio/intestinal-tissue/

(written article with transcript of the interview) https://www.wsws.org/en/articles/2022/07/09/f425-j09.html

Abstract: The world continues to contend with successive waves of coronavirus disease 2019 (COVID-19), fueled by the emergence of viral variants. At the same time, persistent, prolonged and often debilitating sequelae are increasingly recognized in convalescent individuals, named...