viral persistence

Long-Term Dysfunction of Taste Papillae in SARS-CoV-2 BACKGROUND We sought to determine whether ongoing taste disturbance in the postacute sequelae of coronavirus disease 2019 period is associated with persistent virus in primary taste tissue. METHODS We performed fungiform papillae biopsies...

IIMEC15 08 Professor Maureen Hanson 15th Invest in ME Research International ME Conference 2023 29 minutes Terrific presentation from Professor Maureen Hanson including some unpublished work I think we are getting close to some real answers - exhausted t-cells, abnormal classical monocytes...

Lindsey B. Crawford, a ,* Nicole L. Diggins, a Patrizia Caposio, a and Meaghan H. Hancock a Abstract Human cytomegalovirus (HCMV) is a highly prevalent beta-herpesvirus and a significant cause of morbidity and mortality following hematopoietic and solid organ transplant, as well as the leading...

https://www.bmj.com/content/382/bmj.p1156 Feature Covid Unanswered Questions Where do viruses hide in the human body? BMJ 2023; 382 doi: https://doi.org/10.1136/bmj.p1156 (Published 04 July 2023)Cite this as: BMJ 2023;382:p1156 Andy Extance, freelance journalist The question of how...

imPROving Quality of LIFe In the Long COVID Patient (PROLIFIC) https://clinicaltrials.gov/ct2/show/NCT05823896 Petter Brodin Karolinska Institutet, Sweden "Brief Summary: The purpose of this study is to investigate the efficacy of orally administered nirmatrelvir/ritonavir compared with...

Neurologic sequelae of COVID-19 are determined by immunologic imprinting from previous coronaviruses Spatola, Marianna; Nziza, Nadège; Jung, Wonyeong; Deng, Yixiang; Yuan, Dansu; Dinoto, Alessandro; Bozzetti, Silvia; Chiodega, Vanessa; Ferrari, Sergio; Lauffenburger, Douglas A; Mariotto, Sara...

Viral persistence, reactivation, and mechanisms of long COVID Benjamin Chen; Boris Julg; Sindhu Mohandas; Steven B Bradfute; RECOVER Mechanistic Pathways Task Force; Zaki A Sherif; Christian R Gomez; Thomas J Connors; Timothy J Henrich; W Brian Reeves; K Coombs; C Kim; Pras Jagannathan...

Highlights• Cellular stress provokes activation of viral replication in an RNA virus model The viral replication factories are liquid-like condensates that coarsen under stress Stress-triggered IDR phosphorylation stabilizes the viral replication machinery In-cell nucleocapsid structures reveal...

SARS-CoV-2 Spike Protein Accumulation in the Skull-Meninges-Brain Axis: Potential Implications for Long-Term Neurological Complications in post-COVID-19 Zhouyi Rong; Hongcheng Mai; Saketh Kapoor; Victor Puelles; Jan Czogalla; Julia Schaedler; Jessica Vering; Claire Delbridge; Hanno Steinke...

Key Points Question Is treatment with nirmatrelvir in the acute phase of SARS-CoV-2 infection associated with a lower risk of post–COVID-19 condition (PCC)? Findings In this cohort study of 281 793 people with SARS-CoV-2 infection who had at least 1 risk factor for progression to severe...

https://www.frontiersin.org/articles/10.3389/fmed.2022.1003103/full Introduction: Long COVID, or post-acute sequelae of SARS-CoV-2 infection (PASC) in ∼30% of all infected individuals. Here, we present a case of PASC in a patient with rheumatoid arthritis characterized by viral persistence in...

High number of SARS-CoV-2 persistent infections uncovered through genetic analysis of samples from a large community-based surveillance study Multiple researchers from Universities of Oxford and Northumbria, Office for National Statistics, Wellcome Sanger Institute COVID-19 Surveillance Team...

Persistent alveolar type 2 dysfunction and lung structural derangement in post-acute COVID-19 Andre Figueiredo Rendeiro, Hiranmayi Ravichandran, Junbum Kim, Alain Borczuk, Olivier Elemento, Robert Edward Schwartz SARS-CoV-2 infection can manifest as a wide range of respiratory and systemic...

Persistent Presence of Spike protein and Viral RNA in the Circulation of Individuals with Post-Acute Sequelae of COVID-19 Vaughn Craddock, Aatish Mahajan, Balaji Krishnamachary, Leslie Spikes, PrabhakarChalise, Navneet Kaur Dhillon SARS-CoV-2, the causative agent of COVID-19 disease has...

PolyBio Research Foundation Receives $1.3 Million Gift to Advance the study of SARS-CoV-2 Viral Persistence in patients with LongCovid https://polybio.org/portfolio/intestinal-tissue/

(written article with transcript of the interview) https://www.wsws.org/en/articles/2022/07/09/f425-j09.html

Abstract: The world continues to contend with successive waves of coronavirus disease 2019 (COVID-19), fueled by the emergence of viral variants. At the same time, persistent, prolonged and often debilitating sequelae are increasingly recognized in convalescent individuals, named...