viral persistence

  1. mango

    Open Sweden: imPROving Quality of LIFe In the Long COVID Patient (PROLIFIC) 2023 Brodin et al

    imPROving Quality of LIFe In the Long COVID Patient (PROLIFIC) https://clinicaltrials.gov/ct2/show/NCT05823896 Petter Brodin Karolinska Institutet, Sweden "Brief Summary: The purpose of this study is to investigate the efficacy of orally administered nirmatrelvir/ritonavir compared with...
  2. SNT Gatchaman

    Neurologic sequelae of COVID-19 are determined by immunologic imprinting from previous coronaviruses, 2023, Spatola et al

    Neurologic sequelae of COVID-19 are determined by immunologic imprinting from previous coronaviruses Spatola, Marianna; Nziza, Nadège; Jung, Wonyeong; Deng, Yixiang; Yuan, Dansu; Dinoto, Alessandro; Bozzetti, Silvia; Chiodega, Vanessa; Ferrari, Sergio; Lauffenburger, Douglas A; Mariotto, Sara...
    • SNT Gatchaman
    • Thread
    • brain coronavirus csf immune system immunoglobulin immunologic imprinting long covid persistence viral persistence
    • Replies: 6
    • Forum: Long Covid research
  3. SNT Gatchaman

    Viral persistence, reactivation, and mechanisms of long COVID, 2023, Chen et al.

    Viral persistence, reactivation, and mechanisms of long COVID Benjamin Chen; Boris Julg; Sindhu Mohandas; Steven B Bradfute; RECOVER Mechanistic Pathways Task Force; Zaki A Sherif; Christian R Gomez; Thomas J Connors; Timothy J Henrich; W Brian Reeves; K Coombs; C Kim; Pras Jagannathan...
  4. Mij

    Molecular mechanisms of stress-induced reactivation in mumps virus condensates, 2023, Xiaojie Zhang et al

    Highlights• Cellular stress provokes activation of viral replication in an RNA virus model The viral replication factories are liquid-like condensates that coarsen under stress Stress-triggered IDR phosphorylation stabilizes the viral replication machinery In-cell nucleocapsid structures reveal...
  5. SNT Gatchaman

    SARS-CoV-2 Spike Protein Accumulation in the Skull-Meninges-Brain Axis: Potential Implications for Long-Term Neurological Complications

    SARS-CoV-2 Spike Protein Accumulation in the Skull-Meninges-Brain Axis: Potential Implications for Long-Term Neurological Complications in post-COVID-19 Zhouyi Rong; Hongcheng Mai; Saketh Kapoor; Victor Puelles; Jan Czogalla; Julia Schaedler; Jessica Vering; Claire Delbridge; Hanno Steinke...
    • SNT Gatchaman
    • Thread
    • bone marrow brain coagulation complement long covid meninges neurological disorder neurological symptoms sars-cov-2 skull spike protein viral persistence
    • Replies: 14
    • Forum: Long Covid research
  6. Mij

    Association of Treatment With Nirmatrelvir and the Risk of Post–COVID-19 Condition, 2023, Yan Xie, PhD et al

    Key Points Question Is treatment with nirmatrelvir in the acute phase of SARS-CoV-2 infection associated with a lower risk of post–COVID-19 condition (PCC)? Findings In this cohort study of 281 793 people with SARS-CoV-2 infection who had at least 1 risk factor for progression to severe...
  7. J

    Case report: Treatment of long COVID with a SARS-CoV-2 antiviral and IL-6 blockade in a patient with rheumatoid arthritis and SARS-, Vis. et al. 2022

    https://www.frontiersin.org/articles/10.3389/fmed.2022.1003103/full Introduction: Long COVID, or post-acute sequelae of SARS-CoV-2 infection (PASC) in ∼30% of all infected individuals. Here, we present a case of PASC in a patient with rheumatoid arthritis characterized by viral persistence in...
  8. SNT Gatchaman

    [Preprint] High number of SARS-CoV-2 persistent infections uncovered through genetic analysis of samples from a large community surveillance study

    High number of SARS-CoV-2 persistent infections uncovered through genetic analysis of samples from a large community-based surveillance study Multiple researchers from Universities of Oxford and Northumbria, Office for National Statistics, Wellcome Sanger Institute COVID-19 Surveillance Team...
  9. SNT Gatchaman

    [Preprint] Persistent alveolar type 2 dysfunction and lung structural derangement in post-acute COVID-19, 2022, Rendeiro et al

    Persistent alveolar type 2 dysfunction and lung structural derangement in post-acute COVID-19 Andre Figueiredo Rendeiro, Hiranmayi Ravichandran, Junbum Kim, Alain Borczuk, Olivier Elemento, Robert Edward Schwartz SARS-CoV-2 infection can manifest as a wide range of respiratory and systemic...
  10. SNT Gatchaman

    Persistent Presence of Spike protein and Viral RNA in the Circulation of Individuals with Post-Acute Sequelae of COVID-19, 2022, Craddock+

    Persistent Presence of Spike protein and Viral RNA in the Circulation of Individuals with Post-Acute Sequelae of COVID-19 Vaughn Craddock, Aatish Mahajan, Balaji Krishnamachary, Leslie Spikes, PrabhakarChalise, Navneet Kaur Dhillon SARS-CoV-2, the causative agent of COVID-19 disease has...
  11. SNT Gatchaman

    'Long Covid Research Initiative' and Polybio funded to research viral persistence and antiviral treatments

    PolyBio Research Foundation Receives $1.3 Million Gift to Advance the study of SARS-CoV-2 Viral Persistence in patients with LongCovid https://polybio.org/portfolio/intestinal-tissue/
  12. Sly Saint

    An interview with microbiologist Dr. Diane E. Griffin on Long COVID and viral RNA persistence

    (written article with transcript of the interview) https://www.wsws.org/en/articles/2022/07/09/f425-j09.html
  13. Kalliope

    Nature - Pathological sequelae of long-haul COVID by Mehandru, Merad, 2022

    Abstract: The world continues to contend with successive waves of coronavirus disease 2019 (COVID-19), fueled by the emergence of viral variants. At the same time, persistent, prolonged and often debilitating sequelae are increasingly recognized in convalescent individuals, named...
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