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A Cytokine-based model for the pathophysiology of Long COVID symptoms, 2020, Low et al

Discussion in 'Long Covid research' started by Dolphin, Nov 17, 2020.

  1. Dolphin

    Dolphin Senior Member (Voting Rights)

    This contains quite a lot of discussion of ME/CFS, including in the abstract.

  2. Creekside

    Creekside Senior Member (Voting Rights)

    "These dysregulated microglia are hyperreactive
    to signals from the peripheral immune system, producing an exaggerated and prolonged
    central cytokine response to an otherwise mild immune challenge. The primed
    microglia then become resistant to normal regulation, failing to revert to the quiescent state
    after inflammation resolution"

    That's how I was imagining my disorder even before I knew about ME: the glial cells somehow getting 'stuck' in an abnormal state.

    It's really interesting that long-covid victims get PEM so similarly to PWME.
  3. Ravn

    Ravn Senior Member (Voting Rights)

    Aotearoa New Zealand
    251 references. If nothing else they've put some work into this. Unfortunately over my head so no idea if it makes any sense. But they do seem to have listened to patients about the nature of PEM at least and are not confusing it with post-exertional fatigue. That's always a good start.
    CRS=Cytokine Release Syndrome
    I quickly googled CRS and many of the results were related to cancer treatment side effects; it appears rituximab can cause this. No idea what to make of that piece of information.
    ukxmrv, Michelle, rvallee and 2 others like this.
  4. Jonathan Edwards

    Jonathan Edwards Senior Member (Voting Rights)

    London, UK
    It doesn't make any sense because cytokines do not seem to be released either in ME or Covid much. The bit about cancer drugs is incorrect and irrelevant. I am afraid I think this is an advert for a private healthcare facility touting for business selling the same quackery to Long Covid people as toPWME.
    TiredSam, ukxmrv, TrixieStix and 9 others like this.
  5. Snow Leopard

    Snow Leopard Senior Member (Voting Rights)

    Yeah, nah.

    Old discarded theories become new again?

    I'm a bit bored of this superficial cytokine hype that fails to explain any illness, except the appropriately named cytokine-release syndrome.

    Who cares then? It's like saying that one of the pieces in your 1200 piece jigsaw puzzle is essential because otherwise your jigsaw would be incomplete - yes it matters, but it is not central...

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