A Diet-Sensitive Commensal Lactobacillus Strain Mediates TLR7-Dependent Systemic Autoimmunity, 2018, Zegarra-Ruiz et al

Andy · Dec 20, 2018

Highlights
• L. reuteri colonizes lupus-prone hosts and translocates to MLN, liver, and spleen
• L. reuteri exacerbates TLR7-dependent lupus in conventional and germ-free mice
• Resistant starch ameliorates pDCs, type I IFN pathways, and lupus-related mortality
• Starch diet-derived short-chain fatty acids suppress L. reuteri in vitro and in vivo

Summary
Western lifestyle is linked to autoimmune and metabolic diseases, driven by changes in diet and gut microbiota composition. Using Toll-like receptor 7 (TLR7)-dependent mouse models of systemic lupus erythematosus (SLE), we dissect dietary effects on the gut microbiota and find that Lactobacillus reuteri can drive autoimmunity but is ameliorated by dietary resistant starch (RS). Culture of internal organs and 16S rDNA sequencing revealed TLR7-dependent translocation of L. reuteri in mice and fecal enrichment of Lactobacillus in a subset of SLE patients. L. reuteri colonization worsened autoimmune manifestations under specific-pathogen-free and gnotobiotic conditions, notably increasing plasmacytoid dendritic cells (pDCs) and interferon signaling.

However, RS suppressed the abundance and translocation of L. reuteri via short-chain fatty acids, which inhibited its growth. Additionally, RS decreased pDCs, interferon pathways, organ involvement, and mortality. Thus, RS exerts beneficial effects in lupus-prone hosts through suppressing a pathobiont that promotes interferon pathways implicated in the pathogenesis of human autoimmunity.
Click to expand...

Paywalled at https://www.sciencedirect.com/science/article/pii/S1931312818305912

Lisa108 · Dec 21, 2018

sci hub link

Log in or Sign up

A Diet-Sensitive Commensal Lactobacillus Strain Mediates TLR7-Dependent Systemic Autoimmunity, 2018, Zegarra-Ruiz et al

Andy Committee Member

Lisa108 Senior Member (Voting Rights)

Share This Page

Log in or Sign up

A Diet-Sensitive Commensal Lactobacillus Strain Mediates TLR7-Dependent Systemic Autoimmunity, 2018, Zegarra-Ruiz et al

Andy Committee Member

Lisa108 Senior Member (Voting Rights)

Share This Page

Useful Searches