A possible link between recurrent upper respiratory tract infections and lower cytokine production in Q fever fatigue syndrome (Raijmakers et al,2019)

Tom Kindlon · Apr 21, 2019

Research Article
A possible link between recurrent upper respiratory tract infections and lower cytokine production in patients with Q fever fatigue syndrome
Ruud P.H. Raijmakers
Anne F.M. Jansen
Stephan P. Keijmel
Jos W.M. van der Meer
Leo A.B. Joosten
Mihai G. Netea
Chantal P. Bleeker‐Rovers
First published: 18 April 2019
https://doi.org/10.1002/eji.201848012

The peer review history for this article is available at https://publons.com/publon/10.1002/eji.201848012

Abstract

Besides fatigue, many Q fever fatigue syndrome (QFS) patients also complain of frequently recurring upper respiratory tract infections with severe symptoms.

We investigated whether immunologic dysregulation contributes to these complaints.

Cytokine and chemokine production was measured after stimulating monocytes of QFS patients and sex‐matched healthy controls with LPS and several viral ligands.

The H3K4me3 mark of open chromatin was measured at the promoter regions of cytokines and chemokines that differed significantly from healthy controls.

Monocytes of QFS patients produced significantly less TNFα (P = 0.032), IL‐1β (0.004, 0.024, and 0.008), IL‐6 (0.043), RANTES (0.033), IP‐10 (0.049), MCP‐1 (0.022), IL‐ 13 (0.029), and IL‐10 (0.026) than healthy controls when stimulated with various ligands.

H3K4me3 expression was significantly lower in QFS patients than in healthy controls on the promoter regions of IL‐1β (P = 0.004), MCP‐1 (< 0.001 and < 0.001), IP‐10 (< 0.001), IL‐10 (0.041), and IL‐13 (< 0.001, < 0.001, and 0.001).

QFS patients showed diminished cytokine responses to various stimuli compared to age‐ and sex‐matched healthy controls, likely due to epigenetic remodelling and long‐term memory as a result from the acute Q fever infection.

This might explain the upper respiratory tract ailments in QFS.
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A possible link between recurrent upper respiratory tract infections and lower cytokine production in Q fever fatigue syndrome (Raijmakers et al,2019)

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A possible link between recurrent upper respiratory tract infections and lower cytokine production in Q fever fatigue syndrome (Raijmakers et al,2019)

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