Preprint A Proposed Mechanism for ME/CFS Invoking Macrophage Fc-gamma-RI and Interferon Gamma, 2025, Edwards, Cambridge and Cliff

Yes, from what I've seen - and I haven't looked into it too deeply - it did seem to broadly affect lymphocyte proliferation. And was just wondering how, based on your hypothesis and isoprinosine's mechanism of action, you'd expect this to affect pwME.

I would guess it would do nothing because any general leaning on lymphocytes to do a bit more of this is likely to immediately get offset by mechanisms to ensure a bit more of the other. If you poison lymphocytes in people with RA a bit, mostly nothing happens. You need to interfere in a very precise way. My guess is that ME/CFS will be the same. You will need to interfere in a precise way in the a specific pathway.

And there will be hundreds of people who have ME/CFS or Long Covid who have been exposed to these agents and we don't hear of many miracle cures.
 
I would guess it would do nothing because any general leaning on lymphocytes to do a bit more of this is likely to immediately get offset by mechanisms to ensure a bit more of the other. If you poison lymphocytes in people with RA a bit, mostly nothing happens. You need to interfere in a very precise way. My guess is that ME/CFS will be the same. You will need to interfere in a precise way in the a specific pathway.
Very interesting, thank you!

we don't hear of many miracle cures.
Oh, I didn't want to imply that this could be a miracle cure. Just trying to wrap my head around potential consequences. E.g. as gamma IFN had been found increased in some studies. If I understand your hypothesis correctly, this would/should promote the vicious cycle you describe. But I suppose it's much more complex.
 
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