Interleukin‑37 (IL‑37) is an anti-inflammatory cytokine that broadly suppresses innate immune responses—especially by inhibiting IL‑1β, IFN‑γ, IL‑6, and TNF, etc. ME/CFS patients exhibit elevated pro-inflammatory cytokines, and preclinical evidence suggests that IL‑37 reduces inflammation and restores energy metabolism in mice—directly targeting fatigue mechanisms.
Again, in this context, to make this paper more interesting, the authors should expand the discussion (or introduction) a bit. Below, I report an interesting article that should be studied, incorporated in meaning, and reported in the list of references.
Toniato E. IL-37 is an inhibitory cytokine that could be useful for treating infections .
International Journal of Infection. 2024;8(1):1-2. (
www.biolife-publisher.it).