A Thought Experiment on Muscles

It is, thank you. I think I understand the key metabolic ideas more clearly. Though presumably the central question for any theory to answer is, “how does this cause ME?“ And as you say, this is where you rely on speculation to bridge the gap.

I will bow out at this point, but thanks for taking the time to explain some of the basics to these of us struggling with brain fog.

 

No problem, thanks for engaging! Always happy to break things down for anyone that needs it.

I suspect more of the “how does this lead to ME” puzzle will have to be filled in by non-ME/CFS-specific research.

For example, fatigue in anemia is thought to be caused by insufficient distribution of oxygen for oxidative phosphorylation, which means it has some overlap with the malate NAD/NADH mechanism (with important differences).

but we don’t actually know for sure, at least on a detailed neurobiological level, how that manifests as the feeling of fatigue in anemia. Brain fog and muscle pain are similar question marks.

in the mean time, we can make guesses based on where mechanisms overlap with similar symptoms in other illnesses, and my theory has some decent evidence on that point.