Activation of Transposable Elements in Immune Cells of Fibromyalgia Patients - Ovejero, Oltra et al Dec 2019

Sly Saint · Dec 29, 2019

Version 1 : Received: 26 December 2019 / Approved: 27 December 2019 / Online: 27 December 2019 (03:30:53 CET)

This version is not peer-reviewed

Abstract
The development of nucleic acid sequencing technology and the unprecedented availability of metadata has evidenced that 45% of human genome constituted by transposable elements (TEs) is not only transcriptionally active but also physiologically needed.

Aberrant regulation of TEs, and of human retroviral endogenous sequences (HERVs) in particular, associates with several neurologic and autoimmune diseases, including the Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) frequently comorbid with fibromyalgia (FM). However, no study has yet addressed whether abnormal expression of these sequences correlates with FM.

The work presented here shows, for the first time, that in fact HERVs of the H, K and W types are overexpressed in the cells of the immune system of FM patients with or without comorbid ME/CFS. The patients with increased HERV expression (N=14) presented increased levels of interferon (INF-β and INF-γ) but unchanged levels of TNF-α. In support of our proposal that TE activation is a contributor to FM, we find that the tRNA pools are decreased in comparison to matched healthy participants (N=14).

The findings reported here could explain the flu-like symptoms FM patients present with in the absence of concomitant infections. Future work towards identifying specific genomic loci differentially affected in FM and ME/CFS is granted.
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https://www.preprints.org/manuscript/201912.0358/v1

Hoopoe · Dec 29, 2019

The findings reported here could explain the flu-like symptoms FM patients present with in the absence of concomitant infections.
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It often feels like an infection but nobody can find a pathogen. Maybe something like this is the cause?

lansbergen · Jan 4, 2020

strategist said: ↑

It often feels like an infection but nobody can find a pathogen.
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No known pathogen that can be tested for.

Andy · Feb 21, 2020

Now published. Open access, https://www.mdpi.com/1422-0067/21/4/1366

Sly Saint · Mar 5, 2020

Active Transposable Elements in Immune Cells Can Lead to Flu-Like Symptoms in Fibromyalgia, Study Finds

Article about the study:
https://fibromyalgianewstoday.com/2...ents-immune-cells-can-lead-flu-like-symptoms/

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