immune cells

Tissue-resident immune cells drive genetic risk in autoimmune and lung diseases Abstract Common genetic variants are associated with risk of lung and autoimmune diseases. However, we have a limited understanding of the pathological effects of these disease variants, specifically in...

Necroptosis and Cellular Stress Characterize Immune and Endothelial Dysfunction in Long COVID Abstract Background Long COVID, or Post-Acute Sequelae of SARS-CoV-2 infection (PASC), affects a significant proportion of COVID-19 survivors and is associated with persistent fatigue, dysautonomia...

Systems-level transcriptomic analysis reveals synapse-related gene dysregulation in peripheral leukocytes of MDD patients Major depressive disorder (MDD) involves both central nervous system dysfunction and systemic immune alterations. Using a systems biology approach, we investigated whether...

Long-term sex differences in symptoms and immune profile in long COVID BACKGROUND Long COVID (LC) is a post-infectious condition affecting millions worldwide, characterized by persistent multisystem symptoms. Females are disproportionately affected, reporting higher symptom burden...

I’m trying to look for a possible lead: I recently had high blood-measurements of Circulating Immune Complexes (CIC) at 2 different time points Early September : 130 (reference range 0-20) Half October : 78 (range 0-20) October was AFTER a immune suppressive treatment Note: Circulating...

Highlights • Plasma profiling of 7,288 proteins during post-exertional malaise in ME/CFS. • ME/CFS participants show sustained immune, metabolic, and neuromuscular dysregulation during post-exercise recovery. • Exertion disrupts T and B cell signaling, IL-17 pathways, and mitochondrial...

Investigating apoptosis in peripheral blood mononuclear cells among the elderly in the post-COVID-19 era Abiri, Elaheh; Hemmatian, Najmeh BACKGROUND AND AIM The COVID-19 pandemic has left a lasting imprint on immune function, particularly in the elderly—a population already vulnerable to...

Many disease-associated variants are thought to be regulatory but are not present in existing catalogues of expression quantitative trait loci (eQTL). We hypothesise that these variants may regulate expression in specific biological contexts, such as stimulated immune cells. Here, we used human...

Zheyi Wang, Zetai Bai & Yize Sun Abstract Background Accumulating evidence has hinted at a correlation between immune cells and post-viral fatigue syndrome (PVFS). However, it is still ambiguous whether these associations indicate a causal connection. Objective To elucidate the potential...

https://www.mdpi.com/2227-9059/13/5/1200 Abstract Background/Objectives: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a multifaceted and diverse disorder with an ambiguous etiology. Recent evidence indicates that immune system impairment and inflammatory mechanisms are pivotal...

368 - Relation of Immune Profile to Exercise-Induced Pain and Fatigue in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Post-acute Sequelae of SARS-CoV-2 Infection Giovanni Berardi, Adam Janowski, Samuel McNally, Gregorius Bernhard, Alpana Garg, Kathleen Sluka Abstract Individuals with...

A Mendelian randomization study: causal relationship between immune cells and the risks of social phobia, specific phobia, and agoraphobia Jun-Neng Wang, Dong-Hu Yu, Zhi-Yu Li, Ling-Yue Kong, Nan-Hao Li, You-Xian Wu, Tian-Qing Wang, Ze-Fen Wang & Zhi-Qiang Li [Line breaks added] Background...

I’ve been reading/listening to lots about the immune system, particularly B and T cells. And thought it may be worth sharing some links to info I’ve found useful. If others have useful resources please chip in! There’s a lot of sources here and duplication, I found reading/listening to...

Now published - see here Preprint Identification of a multi-omics factor predictive of long COVID in the IMPACC study Gisela Gabernet; Jessica Maciuch; Jeremy P Gygi; John F Moore; Annmarie Hoch; Caitlin Syphurs; Tianyi Chu; Naresh Doni Jayavelu; David B Corry; Farrah Kheradmand; Lindsey R...

Immune cells mediated the causal relationship between the gut microbiota and anxiety disorders: A Mendelian randomization study Ji-ang Li, Chen-han Zhou, Ze Liu, Hong-bin Guo, Jie-yu Liang, Yi Zhang Highlights A causal relationship between gut microbiota and anxiety disorder (AD) is...

Immune cells play a bigger role in high blood pressure than previously thought, opening doors for new treatments (msn.com)

pH sensing at the intersection of tissue homeostasis and inflammation Stephanie Hajjar; Xu Zhou pH is tightly maintained at cellular, tissue, and systemic levels, and altered pH – particularly in the acidic range – is associated with infection, injury, solid tumors, and physiological and...

SCENITH: A Flow Cytometry-Based Method to Functionally Profile Energy Metabolism with Single-Cell Resolution Rafael J. Argüello; Alexis J. Combes; Remy Char; Julien-Paul Gigan; Ania I. Baaziz; Evens Bousiquot; Voahirana Camosseto; Bushra Samad; Jessica Tsui; Peter Yan; Sebastien Boissonneau...

Human Immune Cell Epigenomic Signatures in Response to Infectious Diseases and Chemical Exposures Wenliang Wang; Manoj Hariharan; Anna Bartlett; Cesar Barragan; Rosa Castanon; Vince Rothenberg; Haili Song; Joseph Nery; Andrew Aldridge; Jordan Altshul; Mia Kenworthy; Wubin Ding; Hanqing Liu; Wei...

Immunomodulation by endothelial cells — partnering up with the immune system? Jacob Amersfoort, Guy Eelen and Peter Carmeliet Blood vessel endothelial cells (ECs) have long been known to modulate inflammation by regulating immune cell trafficking, activation status and function. However...