Alzheimer's and Parkinson's could be halted by a protein that helps hedgehogs hibernate

Sly Saint · Mar 23, 2023

new research has found that there is potential to halt both conditions - by using a protein that helps bears and hedgehogs hibernate.

As reported in the EMBO Molecular Medicine journal, the gene therapy also offers hope of treating stroke and accident victims with acute brain injury.

It is based on "cold-shock chemicals" that enable animals to go to sleep for the winter.

They increase levels of a molecule known as RBM3 that protects neurons from damage.

In experiments, mice prone to neurodegenerative disease were injected with antisense oligonucleotides (ASOs) - compounds that can target any gene.

This was despite them having been infected with rogue proteins called prions that can lead to dementia, Parkinson's and CJD (Creutzfeldt-Jakob Disease).

Lead author Professor Giovanna Mallucci, from the University of Cambridge, said: "Essentially, the cold shock protein enables the brain to protect itself - in this case, against the damage to nerve cells in the brain during prion disease.

"Remarkably, we showed that just a single injection with the ASO was sufficient to provide long-lasting protection for these mice, preventing the inevitable progression of neurodegeneration."

In the early stages of Alzheimer's, and other neurodegenerative disorders, synapses are lost. This inevitably progresses to whole brain cells dying.

But during hibernation, up to a third of these connections in the brain are culled as the body preserves precious resources over winter, and those connections are reformed in the spring, with no loss of memory.

The international team took a step towards harnessing this power by identifying a key element in the cold shock protein gene which prevents expression under normal conditions. Removing it with an ASO resulted in more RBM3.

Twelve weeks after being administered with disease causing prions, control mice succumbed and showed extensive loss of neurons in the hippocampus which controls memory.
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Alzheimer's and Parkinson's could be halted by a protein that helps hedgehogs hibernate (msn.com)

Sid · Mar 23, 2023

In mice!

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Alzheimer's and Parkinson's could be halted by a protein that helps hedgehogs hibernate

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Alzheimer's and Parkinson's could be halted by a protein that helps hedgehogs hibernate

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