Blood flow in sepsis and ME/CFS

Hoopoe

Hoopoe

Senior Member (Voting Rights)
An interesting blog post. It argues that sepsis and ME/CFS have in common what is called “heterogeneous perfusion”.

There is a picture of what that looks like.
zh40241517520001.jpeg


According to the blog, this would explain many of the characteristics of ME/CFS.

https://www.syndromea.org/2019/02/10/blood-flow-in-sepsis-and-me-cfs/
 
This blog called "Syndrome A" currently has 4 posts. https://www.syndromea.org/
  1. On Autism & Chronic Fatigue Syndrome
  2. Why Does ME/CFS Look Like Sepsis?
  3. Blood Flow in Sepsis and ME/CFS
  4. ME/CFS, Sepsis & Glycocalyx
Posts 1 and 3 are discussed separately in the following threads, in different sub-forums ("Methylation; B12; Glutathione; GcMAF" and "Cardiovascular and Respiratory"):
https://www.s4me.info/threads/syndrome-a-on-autism-chronic-fatigue-syndrome.6480/#post-117926
https://www.s4me.info/threads/blood-flow-in-sepsis-and-me-cfs.8103/

I feel the blog deserves a more general discussion. It is essentially about an overarching hypothesis centered on blood vessels. Post 2 gives an overview (long read).

First impressions (I haven't been able to do a focussed read yet, just a quick skim):

The author has read a lot of research.
The author has done a lot of thinking.
The author is asking a lot of good questions.

Here is an interesting excerpt from post 4.
People are known to get sick with ME/CFS after infections of various kinds, after physical injury, and after high emotional stress. After we get sick, additional “crashes” can be triggered by surgery, infections, accidents, or stress. How could we all end up with the same illness from so many different causes? How could so many different things make us feel worse?

A unifying theory might be that all of these events potentially trigger glycocalyx damage.

Glycocalyx is a delicate substance and many events can trigger its destruction. If you have a major injury from an accident or surgery, damage occurs to local blood vessels. Glycocalyx particles break away from the walls of blood vessels at the site of an injury.

These particles act as Damage Associated Molecular Patterns, or DAMPS. DAMPS are inflammatory molecules that originate inside the body and trigger noninfectious inflammation. DAMPS that come from glycocalyx can potentially flow through the blood and trigger inflammation and further glycocalyx damage elsewhere in the body.
Click to expand...
Could this glycocalyx damage explain PEM?

Could these DAMPS molecules be the mystery factor in the blood that makes healthy cells behave like ME cells when placed into ME plasma?
 
It is interesting.

It seems that it is quite easy to get a look at this glycocalyx in the blood vessels in a non-invasive way.



The video is a full-on advert, but it looks as if a video microscope under the tongue can show what condition the glycocalyx is in. The Glycocheck process is presumably a patented algorithm for assessing various factors and coming up with a number - I'm not endorsing the company or their test.
 
Hutan said:
The video is a full-on advert, but it looks as if a video microscope under the tongue can show what condition the glycocalyx is in.
Click to expand...
"Full-on advert" is an understatement! But it did teach me how to pronounce 'glycocalyx'.

Interesting to know that there is a technology widely used in research, at least according to the ad, to look at blood flow in the microvascular system. Would it be suitable to look at blood flow issues in ME, too?
 
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