Brain abnormalities in ME: Eval'n by diffusional kurtosis imaging & neurite orient'n dispers'n & density imaging

adambeyoncelowe · Nov 16, 2018

Brain abnormalities in myalgic encephalomyelitis/chronic fatigue syndrome: Evaluation by diffusional kurtosis imaging and neurite orientation dispersion and density imaging.

Kimura Y1, Sato N1, Ota M2,3, Shigemoto Y1, Morimoto E1, Enokizono M1, Matsuda H4, Shin I5, Amano K6, Ono H7, Sato W7, Yamamura T7.

Link: https://www.ncbi.nlm.nih.gov/pubmed/30430664

Abstract
BACKGROUND:
Diffusional kurtosis imaging (DKI) and neurite orientation dispersion and density imaging (NODDI) metrics provide more specific information regarding pathological changes than diffusion tensor imaging (DTI).

PURPOSE:
To detect microstructural abnormalities in myalgic encephalomyelitis (ME) / chronic fatigue syndrome (CFS) patients by using DKI and NODDI metrics.

STUDY TYPE:
Prospective.

POPULATION:
Twenty ME/CFS patients and 23 healthy controls were recruited.

FIELD STRENGTH/SEQUENCE:
Three-b value DWI (b-values = 0, 1000, and 2000 sec/mm2 ) and 3D T1 -weighted images were at 3.0T.

ASSESSMENT:
Mean kurtosis (MK), neurite density index (NDI), orientation dispersion index (ODI), fractional anisotropy (FA), and mean diffusivity (MD) were calculated.

STATISTICAL TESTING:
The two-sample t-test analysis in SPM12 software was used to compare the differences between ME/CFS and control groups.

RESULTS:
In the ME/CFS patients, we observed significant FA decreases in the genu of the corpus callosum and the anterior limb of the right internal capsule (P < 0.05), but no significant difference in MD (P = 0.164); there were also significant MK decreases in the right frontal area, anterior cingulate gyrus, superior longitudinal fasciculus (SLF), and left parietal area (P < 0.05). Significant NDI decreases were observed in the right posterior cingulate gyrus, SLF, and left frontal area of the ME/CFS patients (P < 0.05). Significant ODI decreases were seen in the bilateral occipital areas, right superior temporal gyrus, the anterior limb of internal capsule, and the posterior cingulate gyrus (P < 0.05), and significant ODI increases were revealed in the bilateral occipital and right temporal areas (P < 0.05).

DATA CONCLUSION:
Right SLF abnormalities may be a diagnostic marker for ME/CFS.

LEVEL OF EVIDENCE:
1 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2018.

© 2018 International Society for Magnetic Resonance in Medicine.

KEYWORDS:
chronic fatigue syndrome; density imaging; diffusional kurtosis imaging; neurite orientation dispersion
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adambeyoncelowe · Nov 16, 2018

Title trimmed to fit.

Hoopoe · Nov 16, 2018

They conclude that the right superior longitudinal fasciculus (SFL) appears to be abnormal.

Montoya et al. previously reported that the "right anterior arcuate fractional anisotropy may serve as a biomarker for CFS".

Trying to understand whether there was a connection, I googled, and the literature that came up says

Dorsal Pathways
These two fiber pathways identified have been discussed by Geschwind: the arcuate fasciculus (AF) and part of the superior longitudinal fasciculus (SLF). They are not easily distinguished and sometimes are placed together in discussion.
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Source https://www.sciencedirect.com/topics/neuroscience/superior-longitudinal-fasciculus

Another article also says

The superior longitudinal fasciculus (SLF) and the arcuate fasciculus (AF) have long been considered synonymous in the human, and these names have been used interchangeably. According to observations in the monkey, however, they are separate entities. The SLF comprises three subcomponents (SLF I, II, and III) linking the parietal lobe association cortices with the frontal lobe. The AF, by contrast, appears to be separate and distinct from the SLF. This chapter presents a historical account of SLF and AF. It reviews the origins of the earlier notions and how the understanding of these fiber bundles became embedded in neurological anatomy and perpetuated in current terminology.
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http://www.oxfordscholarship.com/vi...4233.001.0001/acprof-9780195104233-chapter-13

To me this sounds like the Japanese and the Stanfordians have found abnormalities in the same general area of the brain.

adambeyoncelowe · Nov 16, 2018

Added the link.

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Brain abnormalities in ME: Eval'n by diffusional kurtosis imaging & neurite orient'n dispers'n & density imaging

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