mri

Modality-specific neurovascular coupling via layer-segregated arteriole networks INTRODUCTION The brain continuously adjusts blood flow in response to elevations in neuronal activity through a process known as neurovascular coupling. These vascular responses form the basis of widely used brain...

Excessive Hypocapnic Cerebral Vasoconstriction in Hypermobile Ehlers–Danlos Syndrome Assessed With Real‐Time Magnetic Resonance Imaging During Lower‐Body Negative Pressure Darius A Gerlach; Anja Bach; Laura de Boni; Fiona Fischer; Tatjana Barth; Alex Hoff; Jorge Manuel; Jens Jordan; Andrea...

Perivascular spaces in neuropsychiatric post-COVID syndrome Abstract Persistent neuropsychiatric symptoms after COVID-19 have been found associated with neurovascular dysfunction, but their relationship with the brain’s perivascular spaces (PVS) remains unclear. We examined whether...

Experimental hypoxia to probe neuro-metabolic and vascular dysregulation in ME/CFS: a multimodal proof-of-concept MRI study BACKGROUND Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a poorly understood, debilitating multisystem condition. Converging evidence implicates impaired...

Peripheral metabolic signatures in patients with neuropsychiatric long COVID syndrome Neuropsychiatric symptoms are considered the most common feature of long COVID disease. Recent studies have demonstrated structural brain changes and highlighted the importance of neuroinflammation in the...

The Mammillary Body-Fornix Gate in Long COVID An exploratory structural and diffusion MRI study of tremor-like symptoms, internal vibrations, and neuromuscular fatigue BACKGROUND Long COVID frequently includes post-exertional malaise, neuromuscular fatigue, internal vibrations, tremor-like...

Central origin of fatigability in Myalgic encephalomyelitis/chronic fatigue syndrome revealed by multimodal neuroimaging Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a debilitating chronic disease characterized by physical and mental fatigue, post-exertional malaise, muscle...

Cerebral gray matter volumes in long-term post-COVID patients are associated with peripheral kynurenine pathway metabolites and the severity of depressive symptoms BACKGROUND Structural brain changes and immune-metabolic alterations are widely reported in post-COVID condition (PCC)...

Patterns of Muscle Health in Single- and Multi-Site Chronic Pain: A UK Biobank Normative Modeling Study BACKGROUND Chronic pain is associated with impaired muscle health, but whether these changes reflect site-specific factors, broader systemic factors, or both remains unclear. The purpose of...

Abstract Objectives Long COVID presents a significant health burden with limited treatment options. Physical activity (PA) has been suggested for self-management, yet symptom worsening has been reported in similar patient populations. This study aims to identify PA’s perceived impact on physical...

7 Tesla MRI links poorer cognitive function to higher perivascular space burden in neuroPASC Purpose Post-acute sequalae of SARS-CoV-2 (PASC) are associated with persistent neurological symptoms (neuroPASC). Perivascular spaces (PVS) in the brain may enlarge in the context of inflammation...

Reduced cortical brain perfusion following COVID-19 infection: impact of COVID-19 severity and relation to memory performance INTRODUCTION Changes to brain perfusion may be contributing to long-term cognitive dysfunction following COVID-19 infection. Lower brain perfusion beyond the acute...

Decreased functional connectivity in post-COVID syndrome patients with high neuroinflammatory activity INTRODUCTION Previous research suggests some post-COVID patients with neurocognitive complaints (NCC) show neuroinflammation. Like in inflammatory diseases, this may affect network...

https://academic.oup.com/cercor/article-abstract/36/3/bhag022/8539773?redirectedFrom=fulltext Abstract The coronavirus disease 2019 (COVID-19) pandemic has not only challenged global public health but also generated interest in its neurological basis. A growing number of neuroimaging studies...

Blood-brain barrier disruption, traumatic encephalopathy, and cognitive decline in retired athletes Cerebrovascular disruption has been implicated in the pathophysiology of head trauma and chronic traumatic encephalopathy (CTE). However, the long-term consequences of repetitive head trauma on...

ABSTRACT Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating disorder with suspected neuroinflammatory pathophysiology. However, previous diffusion tensor imaging (DTI) studies have reported inconsistent white matter abnormalities in ME/CFS, and specific white...

Post COVID-19 condition is associated with altered regional cerebral blood volume as revealed by dynamic susceptibility contrast MRI BACKGROUND Coronavirus disease 2019 (COVID-19) has been associated with central nervous system dysfunction implicating cerebrovascular and neurovascular units...

Preprint. See post #6 for peer-reviewed version. Multimodal imaging suggests potential immune-vascular contributions to altered regional brain perfusion and oxygen metabolism in Post-COVID-19 Syndrome Post-COVID-19 Syndrome (PCS) frequently presents with persistent fatigue, cognitive...

Microstructural White Matter Impairments in Chronic Fatigue Syndrome: Evidence of Segmental Injury in the Cingulum Bundle BACKGROUND Chronic fatigue syndrome (CFS) is a neurological disorder characterized by persistent fatigue. Previous studies have shown structural and functional brain...

Structural brain abnormalities and neuropsychiatric symptoms in post-COVID condition OBJECTIVES We aimed to cross-sectionally and longitudinally compare brain morphometry and neuropsychiatric symptoms, and evaluate their relationship, in participants with Post-Coronavirus Disease Condition...