Brunel University London - Reactivation of herpesviruses in Chronic Fatigue Syndrome

Sly Saint · Nov 9, 2022

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome affects an estimated 24 million people worldwide, of whom around a quarter are severely affected and are house- or bed-bound, and it strikes people in their prime of life, causing enormous personal and societal economic costs. Few people recover completely from ME/CFS, although symptoms can fluctuate. There is no diagnostic test for ME/CFS, and the lack of understanding of disease mechanisms is preventing the development of rational treatments.

There is an overlap in clinical presentation with some people experiencing Long COVID, including post-viral fatigue and brain fog, potentially caused by similar disease mechanisms. It is characterised by persistent or recurrent incapacitating fatigue and the worsening of symptoms following even minor physical or mental exertion, alongside symptoms affecting the immune, endocrine and neural systems.

Human Herpesviruses (HHVs) have been speculatively implicated in ME/CFS pathogenesis, but there is no correlation between infection per se and ME/CFS development. Most people are infected with HHVs early in life and do not experience any symptoms due to an effective immunological system.

We hypothesise that the characteristic persistent remitting and relapsing nature of the ME/CFS syndrome in many individuals is the result of repeated HHV-6B reactivation, due to abnormal immune responses in susceptible people following an initial triggering event such as infection with another virus. In a small pilot study, we found that the concentration of DNA from HHV-6B was higher in saliva from people with ME/CFS, and that the concentration correlated with the severity of symptoms.

We were unable to determine whether HHV-6B reactivation directly caused the symptoms, or whether it was a result of another ME/CFS disease process.

In our current project, we are performing a larger-scale prospective virologic study, with people with mild/moderate or severe ME/CFS alongside healthy people. We are asking our study participants to record their symptom severity frequently, so that we can determine whether changes in HHV-6B concentration in saliva occur before or after changes in ME/CFS symptoms.

In this way, we aim to determine whether HHV-6B causes the symptom changes or if these occur after the disease gets worse. We are also investigating immune cell function in people with ME/CFS and/or Long COVID: specifically, we are looking at cytotoxic T cells, including their responses to stimulation and at the impact of HHV-6B on their interaction with other immune cells.

We will gain a better understanding of the role of herpesviruses, particularly HHV-6B, in the onset and progression of ME/CFS and Long COVID, which will lead to the development of specific drug treatments, including anti-viral therapy and drugs to boost the immune system appropriately. It will also help with the development of diagnostic and prognostic markers for ME/CFS.
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https://www.brunel.ac.uk/research/projects/reactivation-of-herpesviruses-in-chronic-fatigue-syndrome

Mij · Nov 9, 2022

I can testify that my baseline went lower after a reactivation of HHV6 and EBV from taking immune modulators. I also developed orthostatic impairment.

This occurred 11 years after ME onset

MeSci · Nov 9, 2022

"which will lead to the development of specific drug treatments".

Rather optimistic!

John Mac · Nov 9, 2022

MeSci said: ↑

"which will lead to the development of specific drug treatments".

Rather optimistic!
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I wonder if this is the language they have to use when applying for grants?

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Brunel University London - Reactivation of herpesviruses in Chronic Fatigue Syndrome

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