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SARS-CoV-2 spike-driven reactivation of latent herpesviruses as a mechanistic link to post-viral diseases Jana, Manoj K.; Nora-Krukle, Zaiga; Prusty, Bhupesh K. Significance Persistent symptoms following viral infections are increasingly recognized, yet the biological mechanisms driving...

Full title: Chronic Reactivation of Persistent Human Herpesviruses EBV, HHV-6 and VZV and Heightened Anti-dUTPase IgG Antibodies Are a Recurrent Hallmark in Post-Infectious ME/CFS and is Associated With Fatigue ABSTRACT Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a...

Apostolos P. Georgopoulos, Lisa M. James & Philip K. Peterson Abstract Viral infections have been widely implicated in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) pathogenesis. Recent evidence has also identified certain Human Leukocyte Antigen (HLA) alleles that are...

Seasonal Coronavirus-Induced Immunological Imprinting and Previous Herpesvirus Infections in Patients With Long COVID Long COVID (LC) is a post-acute infection syndrome affecting 5%–10% of individuals infected by SARS-CoV-2. Here, we aimed to study SARS-CoV-2 humoral immunity, immunological...

ABSTRACT Objectives Herpesviruses are ubiquitous and after primary infection they establish lifelong latency. The impairment of maintaining latency with short-term or long-term consequences could be triggered by other infection. Therefore, reactivation of herpesviruses in COVID-19 patients...

Cardiovascular and haematological pathology in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): A role for viruses Nunes, Kell, Pretorius ME/CFS is a debilitating chronic condition that often develops after viral or bacterial infection. Insight from the study of Long COVID/Post...

The herpes simplex virus hides in the body’s immune cells, increasing its survival chances. This finding from offers a new target for vaccines to clear latent infection. Abstract A hallmark of herpes simplex virus (HSV) infection is the establishment of latent virus in peripheral sensory...

https://www.brunel.ac.uk/research/projects/reactivation-of-herpesviruses-in-chronic-fatigue-syndrome

"Herpes simplex virus (HSV) establishes latency in ganglionic neurons of the peripheral nervous system, from which it can reactivate, causing recurrent disease and possible transmission to a new host. Current anti-HSV therapy does not eliminate latent HSV, and thus is only suppressive rather...

Alzheimer’s disease can begin almost imperceptibly, often masquerading in the early months or years as forgetfulness that is common in older age. What causes the disease remains largely a mystery. But researchers at Tufts University and the University of Oxford, using a three-dimensional human...

vvv Source: Medical Immunology Vol 23, #4, pp 975-980 Date: July/August 2021 URL: https://www.mimmun.ru/mimmun/article/view/2439 https://www.mimmun.ru/mimmun/article/view/2439/1456 Early diagnostics of autoinflammatory disorders associated with post-viral chronic fatigue...

Paywall, https://link.springer.com/article/10.1007/s13365-021-00952-6

Myalgic encephalomyelitis/chronic fatigue syndrome and gulf war illness patients exhibit increased humoral responses to the herpesviruses-encoded dUTPase: Implications in disease pathophysiology Peter Halpin 1, Marshall Vance Williams 1 2, Nancy G Klimas 3 4, Mary Ann Fletcher 3 4, Zachary...

This study received significant funding from the US NIH but it doesn't seem a paper will be published. I'm guessing they only received funding for R21 to do feasibility work and that work allowed them to develop a test but only test a small cohort. US NIH Project Description Source ...

There are at least eight herpes virus variants that infect humans. These include: Human herpes virus 1 (HHV1) is also known as herpes simplex virus 1 (HSV1). Human herpes virus 2 (HHV2) is also called herpes simplex virus 2 (HSV2). Human herpes virus 3 (HHV3) is also called varicella-zoster...