herpesvirus

SARS-CoV-2 spike-driven reactivation of latent herpesviruses as a mechanistic link to post-viral diseases Jana, Manoj K.; Nora-Krukle, Zaiga; Prusty, Bhupesh K. Significance Persistent symptoms following viral infections are increasingly recognized, yet the biological mechanisms driving...

Does Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Represent a Poly-Herpesvirus Post-Virus Infectious Disease? Ariza, Maria Eugenia; Mena Palomo, Irene; Williams, Marshall V. [Line breaks added] Abstract Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a...

Full title: Chronic Reactivation of Persistent Human Herpesviruses EBV, HHV-6 and VZV and Heightened Anti-dUTPase IgG Antibodies Are a Recurrent Hallmark in Post-Infectious ME/CFS and is Associated With Fatigue ABSTRACT Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a...

Apostolos P. Georgopoulos, Lisa M. James & Philip K. Peterson Abstract Viral infections have been widely implicated in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) pathogenesis. Recent evidence has also identified certain Human Leukocyte Antigen (HLA) alleles that are...

Seasonal Coronavirus-Induced Immunological Imprinting and Previous Herpesvirus Infections in Patients With Long COVID Long COVID (LC) is a post-acute infection syndrome affecting 5%–10% of individuals infected by SARS-CoV-2. Here, we aimed to study SARS-CoV-2 humoral immunity, immunological...

[...] Herpesviruses and a Faulty Antiviral Response may Contribute to Chronic Multi-Symptom and Multi-System Illnesses in U.S. Military Veterans Brandon Cox, Paula Goolkasian, Irene Mena Palomo, Marshall V. Williams, Sean R. Maloney, Maria Eugenia Ariza [Line breaks added] ABSTRACT Chronic...

Introduction. After the acute form of COVID-19, 10 to 30% of patients tend to develop a post-covid syndrome or long-COVID-19. Research is actively being conducted into the causes of long-term COVID-19, one of which may be a violation of the immune response after SARS-CoV2 enters the body as a...

Editor’s summary Infection with herpes simplex virus type 1 (HSV-1) is common, lifelong, and often in a latent state with periodic reactivation. It is a risk factor for neurodegenerative disease and dementia in some individuals, as are repeated head injuries like concussions. Cairns et al. found...

Full title: From human herpes virus-6 reactivation to autoimmune reactivity against tight junctions and neuronal antigens, to inflammation, depression, and chronic fatigue syndrome due to Long COVID Abstract Inflammation and autoimmune responses contribute to the pathophysiology of Long COVID...

Abstract Myalgic Encephalomyelitis / Chronic Fatigue Syndrome is a debilitating, multisystem disease of unknown mechanism, with a currently ongoing search for its endocrine mediators. Circulating microRNAs (miRNA) are a promising candidate for such a mediator and have been reported as...

The viral origin of myalgic encephalomyelitis/chronic fatigue syndrome Maureen R. Hanson Sections — Can any infection lead to ME/CFS? Why is the enterovirus family the most likely culprit in ME/CFS? What is the relationship between human herpesviruses (HHVs) and ME/CFS? Should the...

The incidence of human herpesvirus (HHVs) is gradually increasing and has affected a wide range of population. HHVs can result in serious consequences such as tumors, neonatal malformations, sexually transmitted diseases, as well as pose an immense threat to the human health. The cGAS-STING...

Recognition of herpesviruses by the innate immune system Paludan, Søren R.; Bowie, Andrew G.; Horan, Kristy A.; Fitzgerald, Katherine A. Advances in innate immunity over the past decade have revealed distinct classes of pattern recognition receptors (PRRs) that detect pathogens at the cell...

Latent virus reactivation in astronauts on the international space station Mehta, Satish K.; Laudenslager, Mark L.; Stowe, Raymond P.; Crucian, Brian E.; Feiveson, Alan H.; Sams, Clarence F.; Pierson, Duane L. Reactivation of latent herpes viruses was measured in 23 astronauts (18 male and 5...

Cardiovascular and haematological pathology in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): A role for viruses Nunes, Kell, Pretorius ME/CFS is a debilitating chronic condition that often develops after viral or bacterial infection. Insight from the study of Long COVID/Post...

The herpes simplex virus hides in the body’s immune cells, increasing its survival chances. This finding from offers a new target for vaccines to clear latent infection. Abstract A hallmark of herpes simplex virus (HSV) infection is the establishment of latent virus in peripheral sensory...

Kaposi's sarcoma-associated herpesvirus (KSHV) utilizes the NDP52/CALCOCO2 selective autophagy receptor to disassemble processing bodies Robinson CA, Singh GK, Kleer M, Katsademas T, Castle EL, Boudreau BQ, Corcoran JA Kaposi’s sarcoma-associated herpesvirus (KSHV) causes the inflammatory and...

Potent Antiviral Activity against HSV-1 and SARS-CoV-2 by Antimicrobial Peptoids Diamond G, Molchanova N, Herlan C, Fortkort JA, Lin JS, Figgins E, Bopp N, Ryan LK, Chung D, Adcock RS, Sherman M, Barron AE Viral infections, such as those caused by Herpes Simplex Virus-1 (HSV-1) and SARS-CoV-2...

https://www.brunel.ac.uk/research/projects/reactivation-of-herpesviruses-in-chronic-fatigue-syndrome

"Herpes simplex virus (HSV) establishes latency in ganglionic neurons of the peripheral nervous system, from which it can reactivate, causing recurrent disease and possible transmission to a new host. Current anti-HSV therapy does not eliminate latent HSV, and thus is only suppressive rather...