Cardiac autonomic function in patients with early multiple sclerosis 2021, Richard Imrich et al

Mij · Mar 5, 2021

Abstract
Purpose
Cardiac autonomic dysfunction has been reported in patients with long-standing multiple sclerosis (MS); however, data in early disease are limited. The present study was aimed at evaluating cardiac autonomic function in patients with early MS in the context of white matter metabolic status, which could potentially affect functions of the autonomic brain centers.

Methods
Cardiac sympathetic and baroreflex cardiovagal responses to the Valsalva maneuver, orthostatic test, and the Stroop test were evaluated in 16 early, treatment-naïve patients with relapsing–remitting MS, and in 14 healthy participants. Proton magnetic resonance spectroscopic imaging (MRSI) of the brain was performed in eight of these MS patients and in eight controls.

Results
Valsalva maneuver outcomes were comparable between patients and controls. At baseline, norepinephrine levels were lower (p = 0.027) in MS patients compared to controls. The patients had higher heart rate (p = 0.034) and lower stroke volume (p = 0.008), but similar blood pressure, cardiac output and norepinephrine increments from baseline to 2 min of the orthostatic test compared to controls. MS patients and controls did not differ in responses to the Stroop test. MRSI showed lower total N-acetylaspartate/total creatine (p = 0.038) and higher myo-inositol/total creatine (p = 0.013) in MS lesions compared to non-lesional white matter.

Conclusion
Our results show normal cardiac sympathetic and baroreflex cardiovagal function in MS patients with relapsing–remitting MS with lesions at the post-acute/early resolving stage.
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https://link.springer.com/article/10.1007/s10286-021-00790-w

Mithriel · Mar 6, 2021

Heart problems and so on happen in diabetes as a result of nerve damage caused by years of disease. It makes sense that it is the same in MS. The same thing may happen in ME.

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Cardiac autonomic function in patients with early multiple sclerosis 2021, Richard Imrich et al

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