CD24 expression and B cell maturation shows a novel link with energy metabolism: potential implications for patients with ME/CFS, 2018, Mensah et al

Currently abstract only at moment at https://www.frontiersin.org/articles/10.3389/fimmu.2018.02421/abstract

 

There's a bit more about this in Cort Johnson recent blog on SCMI Ramsay awards.

 

I struggled to understand what they found out in this paper (in layman`s terms), anyone help?

 

Perhaps @Jonathan Edwards might like to respond

 

I think this IiME blog by Jo Cambridge is about this study?

http://www.investinme.org/ce-blog-1...a2OpOl5i6Gi75zQs9yiIjhwbq93r0h0Nk0QhgGj90rx8c

 

Thanks for sharing, that was a bit easier to understand! So they concluded that the abnormal expression might be due to the patient b cells trying to function normally? Considering Ritux didnt show significant effect in phase 3, some sort of downstream adaptation makes some sense i guess.

Man all these abnormalities puzzles me.. That they can be so many and that were still in limbo trying to close in on the causative events. Can`t wait till someone figures it out

 

Is there anything working right in our M.E bodies??

 

If we are not producing enough ATP because of an impaired aerobic system (so we get 2 ATP instead of 36 for every oxygen molecule) then it makes sense that nothing in our bodies works properly.

It is like a fault in the generator supplying energy to a house. The fridge will work as long as the cooker isn't on, using the hoover will stop the TV and so on.

 

Yes, got it wrong. I know these things then I try to say it and get it upside down, ME brain. I don't think all our cells are affected, that is why we are all so different. If only 10% of cells in each system is affected then it will work fine until a demand is made on it where it will reach a limit quickly.

I have psoriasis, an autoimmune disease where the skin cells grow too quickly, but it only appears in patches. In MS, only some nerve cells are demyelinated even if the immune system wrongly attacks. Very possible this is happening in ME.

In type 1 diabetes, the entire pancreas is not attacked at once either. Strange when you think about it. It is only things like a peanut allergy which cause an overwhelming reaction of the immune system. I wish I could work as a researcher, there are so many questions I would like to answer.

 

I agree that ME is the body running in an " energy conservation mode". Low T3 would also point to this. Low magnesium/ calcium issues affects cellular pumps, and if ATP is involved in distress purnergic signalling it may compound issues.
How each person downregulates, and how this is modulated may be affected by gene expression ( and potentially epigenetic gene expression) - hence why manifestations are different and different things affect different people.
I think there will be a number of common pathways uncovered as science develops the " tools" needed to unpick things.

 

Does anyone understand how these findings relate to ME/CFS?

 

Interesting to see that this is the most viewed paper in the journal this year. It seems that people are interested in the science of ME after all.

I think the point is that (1) there seems to be a shift in young B cell populations involving the marker CD24. (2) much of the paper is about CD24 being involved in diverting cells down one metabolic pathway rather than another. The implication as I see it is that if we are looking for some general metabolic shift in ME then maybe CD24 is a marker of how that is affecting the immune response.

 

There's that senescence thing popping up again (my para breaks) :

Old B cells; old muscles etc :

https://www.s4me.info/threads/old-m...fatigue-syndrome-2018-pietrangelo-et-al.6393/

 

https://meaustralia.net/2018/11/14/...-immune-dysfunction-and-metabolism-in-me/amp/

 

IRF4 and FOXO1 are involved at pro B stage
https://www.researchgate.net/figure...ll-differentiation-and-the-key_fig1_230895853

 

Doesn’t feel like it in mine!

 

Would missing pro B be a bit like bruton but not bruton and would rituximab worsen it who knows
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1905597/#!po=0.657895