mango
Senior Member (Voting Rights)
Characterization and Intervention Studies in Patients with Postural Orthostatic Tachycardia Syndrome and Inappropriate Sinus Tachycardia Associated with Post-Acute COVID-19 Syndrome
Principal Investigator: Dr. Marcus Stahlberg [Ståhlberg], Karolinska University, Sweden
"The overall purpose of this project is two-fold. First, the researchers aim to describe the biological mechanisms and identify potential novel therapeurtic targets in Long COVID patients with cardiovascular autonomic dysfunction (postural orthostatic tachycardia syndrome, inappropriate sinus tachycardia, tachycardia not meeting the POTS or IST criteria) and microvascular endothelial dysfunction.
Long COVID patients from clinics around Sweden will be screened using tilt table and other autonomic testing, mast cell activation syndrome biomarkers, lipidomics, proteomics (mass spectrometry), stress-perfusion cardiac MRI, assessment of endothelial function, 6 minute walk test, quality of life and other self-reported screenings from the time of Long COVID diagnosis until four years after diagnosis.
The second stage of the study includes randomized placebo controlled, double-blinded clinical trials assessing the efficacy of various interventions, including ivabradine, naltrexone, fulvic acid and enhanced external counter pulsation (EECP).
The goal is to deliver rapid evidence-based treatments and to discover novel therapeutic targets that can benefit other Long COVID, POTS and IST patients."
https://dysautonomiainternational.salsalabs.org/2021researchgrants/index.html
Principal Investigator: Dr. Marcus Stahlberg [Ståhlberg], Karolinska University, Sweden
"The overall purpose of this project is two-fold. First, the researchers aim to describe the biological mechanisms and identify potential novel therapeurtic targets in Long COVID patients with cardiovascular autonomic dysfunction (postural orthostatic tachycardia syndrome, inappropriate sinus tachycardia, tachycardia not meeting the POTS or IST criteria) and microvascular endothelial dysfunction.
Long COVID patients from clinics around Sweden will be screened using tilt table and other autonomic testing, mast cell activation syndrome biomarkers, lipidomics, proteomics (mass spectrometry), stress-perfusion cardiac MRI, assessment of endothelial function, 6 minute walk test, quality of life and other self-reported screenings from the time of Long COVID diagnosis until four years after diagnosis.
The second stage of the study includes randomized placebo controlled, double-blinded clinical trials assessing the efficacy of various interventions, including ivabradine, naltrexone, fulvic acid and enhanced external counter pulsation (EECP).
The goal is to deliver rapid evidence-based treatments and to discover novel therapeutic targets that can benefit other Long COVID, POTS and IST patients."
https://dysautonomiainternational.salsalabs.org/2021researchgrants/index.html