Chronic Fatigue Syndrome: Exercise Performance Related to Immune Dysfunction. Nijs et al. 2005

John Mac · Feb 18, 2020

Abstract and Introduction

Purpose: To date, the exact cause of abnormal exercise response in chronic fatigue syndrome (CFS) remains to be revealed, but evidence addressing intracellular immune deregulation in CFS is growing. Therefore, the aim of this cross-sectional study was to examine the interactions between several intracellular immune variables and exercise performance in CFS patients.

Methods: After venous blood sampling, subjects (16 CFS patients) performed a maximal exercise stress test on a bicycle ergometer with continuous monitoring of cardiorespiratory variables.
The following immune variables were assessed:
the ratio of 37 kDa Ribonuclease (RNase) L to the 83 kDa native RNase L (using a radiolabeled ligand/receptor assay),
RNase L enzymatic activity (enzymatic assay),
protein kinase R activity assay (comparison Western blot), elastase activity (enzymatic-colorimetric assay),
the percent of monocytes,
and nitric oxide determination (for monocytes and lymphocytes; flow cytometry, live cell assay).

Results: Forward stepwise multiple regression analysis revealed
1) that elastase activity was the only factor related to the reduction in oxygen uptake at a respiratory exchange ratio (RER) of 1.0 (regression model: R2 = 0.53, F (1,14) = 15.5, P < 0.002; elastase activity P < 0.002);
2) that the protein kinase R activity was the principle factor related to the reduction in workload at RER = 1.0; and
3) that elastase activity was the principle factor related to the reduction in percent of target heart rate achieved.

Conclusion: These data provide evidence for an association between intracellular immune deregulation and exercise performance in patients with CFS. To establish a causal relationship, further study of these interactions using a prospective longitudinal design is required.

Previous research has shown that patients with chronic fatigue syndrome (CFS) present with an abnormal exercise response and exacerbation of symptoms after physical activity. Some of the main findings were a reduction in peak oxygen uptake,[2,10] reduction in peak heart rate,[10] earlier exhaustion,[10] and accelerated glycolysis with increased lactate production
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https://www.medscape.com/viewarticle/516556

Edit: Title edited to reflect original year of study publication (2005 not 2020)

Dolphin · Feb 18, 2020

This is a piece on a 2005 paper

John Mac · Feb 18, 2020

Dolphin said: ↑

This is a piece on a 2005 paper
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Weird, I wonder why Medscape are running it today?

Snow Leopard · Feb 19, 2020

Haven't heard much about low-molecular-weight RNASE-L for a long time. I remember getting excited about it when Kenny came to my city, and I bought their book too, but it turned out to be another phantom.

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