nitric oxide

Microvascular Dysfunction and Redox Imbalance in Long COVID ABSTRACT Objective Endothelial and microvascular dysfunction are key features of Long COVID. Disturbances in cellular redox balance, reflected by altered nicotinamide adenine dinucleotide (NAD+/NADH) dynamics, may underlie vascular...

Unpacking The Neurobiologic Origin Of Psychiatric Symptoms In Long Covid Claire Megan Perry Background Neuropsychiatric Long COVID (LC) is a heterogeneous and debilitating disease spanning multiple mental health symptom domains including depression, anxiety, cognitive dysfunction, fatigue, and...

Abstract: Background. Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and irritable bowel syndrome (IBS) frequently co-occur following infection, yet shared genetic architecture at the locus level has not been systematically characterised. Aims. To estimate global and local genetic...

Hidden in the white matter: Current views on interstitial white matter neurons Maximilian Fischer; Maria Kukley The mammalian brain comprises two structurally and functionally distinct compartments: the gray matter (GM) and the white matter (WM). In humans, the WM constitutes approximately half...

Now published, see post #44. Shear Stress Tolerance Threshold, eNOS Uncoupling, and the Two-Threshold Model of Post-Exertional Malaise in Long COVID: A Mechanistic Hypothesis with Implications for Physiotherapy Practice Karipidis, Yiannis K.; Karipidis, Konstantinos Y. Background A subset of...

Scientists discover a brain signal that may trigger autism’s domino effect A tiny brain signaling molecule may spark a chain reaction that pushes key cellular systems into overdrive in autism. Date: March 7, 2026 Source: The Hebrew University of Jerusalem Summary: Researchers have uncovered...

Erythrocytes as a Source of Exerkines Exercise activates many metabolic and signaling pathways in skeletal muscle and other tissues and cells, causing numerous systemic beneficial metabolic effects. Traditionally recognized for their principal role in oxygen (O2) transport, erythrocytes have...

Nitric oxide promotes cysteine N-degron proteolysis through control of oxygen availability Kim, Haeun; Tian, Ya-Min; Ratcliffe, Peter J; Keeley, Thomas P Selected proteins containing an N-terminal cysteine (Nt-Cys) are subjected to rapid, O2-dependent proteolysis via the Cys/Arg-branch of the...

Endothelial TERT drives microvascular phenotype associated with coronary artery disease Erin C. Birch; Yoshinori Nishijima; Shelby N. Hader; Andreas M. Beyer Microvascular endothelial dysfunction is a powerful predictor of future atherosclerotic cardiac events. Our previous studies revealed...

Study links oral microbiome to cognitive function in older adults

340 – Monocyte Dysregulation in PASC With Ongoing Pulmonary Symptoms Thomas K. Awamura, Stefanos Giannakopoulos, Dominic C. Chow, Cecilia M. Shikuma, Gehan Devendra, Vedbar Khadka, Juwon Park Background As the number of COVID-19 survivors amongst the global population continues to rise, the...

The physio-affective symptoms of Long COVID are strongly predicted by the severity of the acute infectious phase, and lowered antioxidant, nitric oxide, and alanine transaminase levels Michael Maes, Chavit Tunvirachaisakul, Laura de Oliveira Semão, Ana Paula Michelin, Andressa Matsumoto...

Now published, see post #6. Preprint: Chronic Viral Reactivation and Associated Host Immune Response and Clinical Outcomes in Acute COVID-19 and Post-Acute Sequelae of COVID-19 Chronic viral infections are ubiquitous in humans, with individuals harboring multiple latent viruses that can...

Abstract Evidence linking the endothelium to cardiac injury in long coronavirus disease (COVID) is well documented, but the underlying mechanisms remain unknown. Here we show that cytokines released by endothelial cells (ECs) contribute to long-COVID-associated cardiac dysfunction. Using...

Follow-up assessment of the microvascular function in patients with long COVID Romanowska-Kocejko; Braczko; Jędrzejewska; Żarczyńska-Buchowiecka; Kocejko; Kutryb-Zając; Hellmann Long COVID is a complex pathophysiological condition. However, accumulating data suggests that COVID-19 is a systemic...

Inhibition of HIF-2α Pathway as a Potential Therapeutic Strategy for Endothelial Dysfunction in Post-COVID Syndrome Andrea Ribeiro; Timon Kuchler; Maciej Lech; Javier Carbajo-Lozoya; Kristina Adorjan; Hans Christian Stubbe; Martina Seifert; Anna Wöhnle; Veronika Kesseler; Johanna Negele; Uwe...

Abstract Background This study investigates the impact of fluctuating lipid levels on endothelial dysfunction. Methods Human aortic and umbilical vein endothelial cells were cultured under varying palmitic acid (PA) concentrations: 0, 50, and 100 μM, and in a variability group alternating...

Disuse-Induced Muscle Fatigue: Facts and Assumptions Sergeeva, Xenia V.; Lvova, Irina D.; Sharlo, Kristina A. Skeletal muscle unloading occurs during a wide range of conditions, from space flight to bed rest. The unloaded muscle undergoes negative functional changes, which include increased...

Red Blood Cell Adenylate Energetics Is Related to Endothelial and Microvascular Function in Long COVID Romanowska-Kocejko, Marzena; Jędrzejewska, Agata; Braczko, Alicja; Stawarska, Klaudia; Król, Oliwia; Frańczak, Marika; Harasim, Gabriela; Smoleński, Ryszard T.; Hellmann, Marcin; Kutryb-Zając...

Indole-3-propionic Acid, a Gut Microbiota-Derived Tryptophan Metabolite, Promotes Endothelial Dysfunction Impairing Purinergic-Induced Nitric Oxide Release in Endothelial Cells Geddo, Federica; Antoniotti, Susanna; Gallo, Maria Pia; Querio, Giulia Different gut microbiota-derived metabolites...