Co‐occurrence of immune‐mediated conditions and endometriosis among adolescents and adult women, Shafrir et al, 2021

Andy · Feb 16, 2021

Bolding mine.

Problem

Associations between immune dysfunction conditions (e.g. systemic lupus erythematous, rheumatoid arthritis) and endometriosis have been observed in adult women, but not assessed among a younger population. We investigated the association between immune‐mediated conditions and endometriosis among young women.

Method of Study
This cross‐sectional analysis in the Women’s Health Study: From Adolescence to Adulthood included 551 participants with surgically‐diagnosed endometriosis (median age=19) and 652 controls without endometriosis (median age=24). Participants completed an expanded Endometriosis Phenome and Biobanking Harmonization Project questionnaire. We used logistic regression to estimate odds ratios (OR) and 95% confidence intervals (CI) to investigate the associations between autoimmune/inflammatory, atopic, chronic pain/fatigue, and endocrine disorders with endometriosis, adjusting for confounders.

Results
Participants with any autoimmune and/or inflammatory condition had an increased odds of co‐occurring endometriosis (OR:1.87; CI:0.92‐3.80), as did participants with allergies (OR:1.76; CI:1.32‐2.36), asthma (OR:1.35; CI:0.97‐1.88), chronic fatigue syndrome and/or fibromyalgia (OR:5.81; CI:1.89‐17.9), or previous mononucleosis (OR:1.75; CI:1.14‐2.68). Odds of endometriosis were lower among participants with eczema (OR:0.68; CI:0.44‐1.04). We observed a positive trend between the number of immune‐mediated conditions and the odds of endometriosis (p‐trend=0.0002). Endocrine disorders were not associated with endometriosis.

Conclusions
Among this population of adolescents and adult women, endometriosis was more likely among participants with autoimmune and/or inflammatory diseases, allergies, asthma, previous mononucleosis infection, and chronic fatigue and/or fibromyalgia. We observed that an increasing number of immune‐mediated conditions was positively associated with endometriosis risk. It is important for clinicians who care for adolescents and women with these conditions to consider endometriosis as a co‐morbidity.
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Paywall, https://onlinelibrary.wiley.com/doi/10.1111/aji.13404

Hutan · Mar 31, 2023

to investigate the associations between autoimmune/inflammatory, atopic, chronic pain/fatigue, and endocrine disorders with endometriosis, adjusting for confounders.
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Among this population of adolescents and adult women, endometriosis was more likely among participants with autoimmune and/or inflammatory diseases, allergies, asthma, previous mononucleosis infection, and chronic fatigue and/or fibromyalgia.
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The authors don't seem to care much about the distinction between chronic fatigue and chronic fatigue syndrome. Given that fatigue is a common symptom of endometriosis, and the data on co-morbidities came from a self-report survey, I don't think we can be sure this study really looked at the association of ME/CFS with endometriosis.

Midnattsol · Mar 31, 2023

Hutan said: ↑

The authors don't seem to care much about the distinction between chronic fatigue and chronic fatigue syndrome.
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Why should they when "leading experts" don't I'm still annoyed about how Wyller got a grant to study adolescents with CFS, and then when the music study came out it was about adolescents with CF that may go on to develop CFS..

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Co‐occurrence of immune‐mediated conditions and endometriosis among adolescents and adult women, Shafrir et al, 2021

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Co‐occurrence of immune‐mediated conditions and endometriosis among adolescents and adult women, Shafrir et al, 2021

Andy Committee Member

Hutan Moderator Staff Member

Midnattsol Moderator Staff Member

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