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PreprintConnecting the Dots Between ME/CFS, HSD/hEDS, Abnormal Fascia, Lymphatic and Glymphatic System Impairment, and Craniocervical Instability, 2025, Lubel
Connecting the Dots Between ME/CFS, HSD/hEDS, Abnormal Fascia, Lymphatic and Glymphatic System Impairment, and Craniocervical Instability
Lubell, Jeffrey
Abstract
This hypothesis paper encourages a comprehensive approach to studying Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) that connects the dots between Hypermobility Spectrum Disorders (HSD) and Hypermobile Ehlers Danlos Syndrome (hEDS), fascial abnormalities, impaired lymphatic and glymphatic systems, spinal conditions like craniocervical instability and Chiari Malformation, and ME/CFS.
The hypothesis is written by an independent researcher mainly writing about his daughter's experience, and building hypotheses on hypotheses and maybes with very little if any solid evidence of any of it as far as I can see.
I sympathise with the wish to help a sick daughter, and wish them well.
"Connecting the Dots Between ME/CFS, HSD/hEDS, Abnormal Fascia, Lymphatic and Glymphatic System Impairment, and Craniocervical Instability". Lubell Jeffrey
Discussion above has jumped straight to Craniocervical instability very fast ( not read) but I am more interested in the other conditions listed since I have solid diagnoses for all except glymphatic system problems.
I didn't know what the glymphatic system is but found this article which I will need to look at.
The glymphatic system is a recently discovered macroscopic waste clearance system that utilizes a unique system of perivascular channels, formed by astroglial cells, to promote efficient elimination of soluble proteins and metabolites from the ...
pmc.ncbi.nlm.nih.gov
Abstract
The glymphatic system is a recently discovered macroscopic waste clearance system that utilizes a unique system of perivascular channels, formed by astroglial cells, to promote efficient elimination of soluble proteins and metabolites from the central nervous system. Besides waste elimination, the glymphatic system may also function to help distribute non-waste compounds, such as glucose, lipids, amino acids, and neurotransmitters related to volume transmission, in the brain. Intriguingly, the glymphatic system function mainly during sleep and is largely disengaged during wakefulness. The biological need for sleep across all species may therefore reflect that the brain must enter a state of activity that enables elimination of potentially neurotoxic waste products, including β-amyloid. Since the concept of the glymphatic system is relatively new, we will here review its basic structural elements, organization, regulation, and functions. We will also discuss recent studies indicating that glymphatic function is suppressed in various diseases and that failure of glymphatic function in turn might contribute to pathology in neurodegenerative disorders, traumatic brain injury and stroke.
My sleep is appalling.
I have begun to speculate whether I have some sort of Occam's issue going on. I can't contribute much more without doing a lot of reading but brainfog will make that slow. Would be interested in whether others have these multiple diagnoses. I also have lipoedema as well as lymphadema. I don't have craniocervical issues. I know St George's were doing research a couple of years ago to see if they could find a link between HEDS and lipoedema but haven't read any results.
The number of hypotheses, and the degree and intensity of debate, about any issue are inverse indexes of how much knowledge and understanding we actually have.
In medicine specifically, I would also add the frequency that it is labelled complex and multi-factorial, best explained by a biopsychosocial perspective, and needing holistic rehabilitative management by multi-disciplinary teams.
(I am old enough to remember when the word 'holistic' was regarded as hippie new-age woo by mainstream medicine. Now it is one of their favourite buzzwords.)
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