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Coupled electrophysiological, hemodynamic, and cerebrospinal fluid oscillations in human sleep, 2019, Fultz et al

Discussion in 'Health News and Research unrelated to ME/CFS' started by Colin, Apr 30, 2021.

  1. Colin

    Colin Established Member (Voting Rights)

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    Nina E. Fultz, Giorgio Bonmassar, Kawin Setsompop, Robert A. Stickgold, Bruce R. Rosen, Jonathan R. Polimeni, Laura D. Lewis.

    Abstract

    Sleep is essential for both cognition and maintenance of healthy brain function. Slow waves in neural activity contribute to memory consolidation, whereas cerebrospinal fluid (CSF) clears metabolic waste products from the brain. Whether these two processes are related is not known. We used accelerated neuroimaging to measure physiological and neural dynamics in the human brain. We discovered a coherent pattern of oscillating electrophysiological, hemodynamic, and CSF dynamics that appears during non–rapid eye movement sleep. Neural slow waves are followed by hemodynamic oscillations, which in turn are coupled to CSF flow. These results demonstrate that the sleeping brain exhibits waves of CSF flow on a macroscopic scale, and these CSF dynamics are interlinked with neural and hemodynamic rhythms.

    Open access: https://science.sciencemag.org/content/366/6465/628
     
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  2. Colin

    Colin Established Member (Voting Rights)

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  3. Jonathan Edwards

    Jonathan Edwards Senior Member (Voting Rights)

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    Hasn't someone already posted this?

    CSF does not clear metabolic waste products from the brain as far as I know.
    This looks like typical misunderstood physiology - which is the common sort I am afraid.
     
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  4. Colin

    Colin Established Member (Voting Rights)

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    Yes, I posted the Quanta article before but the paper hadn't been. It came up in the Sleep Deprivation experiment thread.
     
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  5. Creekside

    Creekside Senior Member (Voting Rights)

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    How are waste products removed? If they're pumped out through astrocytes, do the astrocytes not absorb it from CSF? Regardless of the final 'waste drain', movement of fluid would be important for preventing localized buildups of waste.
     
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