CROI - Conference on Retroviruses and Opportunistic Infections

[EndME]

CROI - Conference on Retroviruses and Opportunistic Infections

At this years CROI conference there were some presentations on Long-COVID (videos can be found at https://www.croiwebcasts.org/portal/ by using search terms such as "Long-Covid" or "post-acute"). There were also presentations of Ebola survives which might be of interest.

The following abstracts/posters of unpublished work have raised discussions in patient communities:

• Peripheral Immune Progression to Long COVID Is Driven by Mitochondrial Gene Transcription
• Persistence of SARS-CoV-2 in Platelets and Megakaryocytes in Long COVID (poster)

 

[SNT Gatchaman]

The summary points from the second poster (by Dominique Salmon's team) are —

• Circulating megakaryocyte frequency is increased in LC
• Megakaryocytes contain SARS-CoV-2 Spike and dsRNA in LC
• Spike is detected in plasma in LC
• Platelets contain SARS-CoV-2 Spike and RNA in LC
• Peripheral serotonin was reduced in LC

 

[SNT Gatchaman]

10 minute talk on megakaryocyte viral reservoir findings by Morgane Bomsel at PolyBio Spring 2024 Symposium.