Curcumin attenuates collagen-induced inflammatory response through the “gut-brain axis”, 2018, Yue et al

Andy

Andy

Retired committee member
Abstract
Background

Previous studies have demonstrated that oral administration of curcumin exhibited an anti-arthritic effect despite its poor bioavailability. The present study aimed to explore whether the gut-brain axis is involved in the therapeutic effect of curcumin.

Methods
The collagen-induced arthritis (CIA) rat model was induced by immunization with an emulsion of collagen II and complete Freund’s adjuvant. Sympathetic and parasympathetic tones were measured by electrocardiographic recordings. Unilateral cervical vagotomy (VGX) was performed before the induction of CIA. The ChAT, AChE activities, and serum cytokine levels were determined by ELISA. The expression of the high-affinity choline transporter 1 (CHT1), ChAT, and vesicular acetylcholine transporter (VAChT) were determined by real-time PCR and immunohistochemical staining. The neuronal excitability of the vagus nerve was determined by whole-cell patch clamp recording.

Results
Oral administration of curcumin restored the imbalance between the sympathetic and parasympathetic tones in CIA rats and increased ChAT activity and expression of ChAT and VAChT in the gut, brain, and synovium. Additionally, VGX eliminated the effects of curcumin on arthritis and ACh biosynthesis and transport. Electrophysiological data showed that curcumin markedly increased neuronal excitability of the vagus nerve. Furthermore, selective α7 nAChR antagonists abolished the effects of curcumin on CIA.

Conclusions
Our results demonstrate that curcumin attenuates CIA through the “gut-brain axis” by modulating the function of the cholinergic system. These findings provide a novel approach for mechanistic studies of anti-arthritic compounds with low oral absorption and bioavailability.
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Open access at https://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-017-1047-7

Article based on paper from Horsetalk - https://www.horsetalk.co.nz/2018/01/07/curcumin-gut-brain-axis-inflammation/
 
@Andy . . . this is very timely. From my own experience I do think there are anti-inflammatory benefits from eating (Wildcrafted) whole root turmeric paste with black pepper.

I've been adding one tsp of paste (uncooked) to my cooked brown rice every other day and have noticed that the upper joints on my little and ring fingers are no longer inflamed since the last few months. I'm considering buying another jar.
 
I tried curcumin at one time. One problem is that you have to eat buckets of the stuff to reach the doses that have been reported as therapeutic in the literature (1 tsp whole root turmeric paste doesn't cut it). And let's not get started about how much is actually absorbed and what form provides the best absorption.

The main thing curcumin did for me was to give me terrible diarrhea, and it actually took a while before I connected that to the tumeric. So if you do try it, watch out for this unpleasant side effect.
 
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