Daratumumab, isatuximab (CD38 drugs)

Utsikt said:
If I’ve understood correctly, the PCT only allows you to file that you might want to register a patent in the member nations, and then you have to go through the entire process for each nation/union etc. that you decide to actually try to get a patent in.
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Ah, you could be right there - I must check. As I said, it's a long time since I've had anything to do with PCT Chapter IIs, although I have encountered the odd PCT/EP more recently.
 
Wits_End said:
Ah, you could be right there - I must check. As I said, it's a long time since I've had anything to do with PCT Chapter IIs, although I have encountered the odd PCT/EP more recently.
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I’m just going off of Wikipedia and google, so you probably understand more of this than I do!
 
neophyte32 said:
He followed the Fluge and Mella protocol; he has been in strict treatment for quite a few years.
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That's disappointing to see...any information on his NK cell count etc?

He says it's stabilised him and he has a mild improvement with exercise tolerance. That could easily be natural fluctuation but maybe some severe pwME need a higher dose or more than one course of treatment.

I'll be very interested to see what happens to the severe patients F&M are looking at as an expansion of the pilot.

It does give one pause that there aren't any stories of major improvement from off label folks so far.
 
V.R.T. said:
That's disappointing to see...any information on his NK cell count etc?

He says it's stabilised him and he has a mild improvement with exercise tolerance. That could easily be natural fluctuation but maybe some severe pwME need a higher dose or more than one course of treatment.

I'll be very interested to see what happens to the severe patients F&M are looking at as an expansion of the pilot.

It does give one pause that there aren't any stories of major improvement from off label folks so far.
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Normal NK cells, I think, if I remember correctly. He had his injections 5 or 6 months ago... Yes, worrying. Maybe it doesn't work very well on the most severe cases... Now I'm really worried...
 
neophyte32 said:
Normal NK cells, I think, if I remember correctly. He had his injections 5 or 6 months ago... Yes, worrying. Maybe it doesn't work very well on the most severe cases... Now I'm really worried...
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Im quite worried too fwiw. However, there are all sorts of factors that could be influencing who responds and who doesn't, esp outside of a controlled setting. All we can do is wait and see what the trials bring. We should know about the pilot expansion with severe cases fairly soon I think, maybe even next week at Charite!
 
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