Diagnosis and Treatment of Chronic Fatigue Syndrome and Myalgic Encephalitis: It's Mitochondria, Not Hypochondria - by Sarah Myhill

strategist said:
I seem to have some glucose regulation issues or something to do with energy metabolism, nothing major, but keto has been harmful whenever I've tried it. Last time I tried it I also had episodes of abnormal brain activity at night ("a storm in the head"). Do you think this suggests an issue with fats used for energy production?
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I don' t know. Storm in the head sounds awful. There is dome thought that T2 levels modulate fat burning. It could be this for my aunt- she has gone from hyperthyroid and partial thyroidectomy in her 30s to hypothyroid now .
 
TiredSam said:
I'm afraid you'll have to stop that:

upload_2018-3-10_13-8-47.pngView attachment 2110
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https://sci-hub.tw/http://onlinelibrary.wiley.com/doi/10.1111/j.1365-277X.2008.00933.x/full

Here is a paper that looked at the issue. Unfortunately I don't think it gives normative data on diet but does say:
Only 5% had a healthy fibre intake and approximately 70% had an unhealthy lifestyle with respect to fat, fruit and vegetable intake. However, the eating habits of the general Dutch population also showed an unhealthy pattern (TNO Voeding, 1998, 2004; Voedingscentrum, 1998; Hildebrandt et al., 2004; Hulshof et al., 2004)
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J Hum Nutr Diet. 2009 Jun;22(3):226-31. doi: 10.1111/j.1365-277X.2008.00933.x. Epub 2009 Feb 17.
The lifestyle of patients with chronic fatigue syndrome and the effect on fatigue and functionalimpairments.
Goedendorp MM1, Knoop H, Schippers GM, Bleijenberg G.
Author information

Abstract
BACKGROUND:
Little is known about the lifestyle of patients with chronic fatigue syndrome (CFS) and its influence on symptoms of CFS. The present study aimed to investigate the lifestyle of patients with CFS, and to assess whether lifestyle factors are related to fatigue and functional impairments.

METHODS:
Two hundred and forty-seven patients fulfilling the Center for Disease Control criteria for CFS were included. Validated questionnaires were used to collect data on lifestyle factors, smoking, intake of alcohol, fat, fibres, fruit and vegetables, body mass index (BMI), fatigue severity and functional impairments.

RESULTS:
Of the CFS patients, 23% smoked, 32% had an unhealthy BMI, and none had an unhealthy alcohol intake. A majority had an unhealthy food intake: 70% had unhealthy fat, fruit and vegetable intake, and 95% had unhealthy fibre intake. Compared with the general Dutch population, significantly fewer CFS patients were overweight. Significantly more female CFS patients abstained from alcohol, and fewer male CFS patients smoked. Unhealthy lifestyle factors were not significantly associated with fatigue severity or functional impairments.

CONCLUSIONS:
CFS patients tend to lead a healthier lifestyle compared to the general Dutch population. However, no relationship was found between lifestyle factors and fatigue severity and functional impairments in CFS.

PMID: 9226353

DOI: 0.1111/j.1365-277X.2008.00933.x
[Indexed for MEDLINE]
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Dolphin said:
https://sci-hub.tw/http://onlinelibrary.wiley.com/doi/10.1111/j.1365-277X.2008.00933.x/full

Here is a paper that looked at the issue. Unfortunately I don't think it gives normative data on diet but does say:
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They also don't give scores, for the most part, or correct for making multiple comparisons outside of the symptom comparisons within the patient group. They also only had BMI data for one-third of patients, which seems dodgy as hell since it's an extremely easy thing to measure and calculate. Since patients were recruited from the Radboud clinic without extra data collected (to avoid the need for ethical approval), they were probably much more likely to have BMI data on obviously overweight patients, especially since they purport to use Fukuda which has a BMI restriction.

But the Dutch concept of a healthy diet involves eating a ton of bread for fiber, which is problematic if patients have a gluten intolerance, and tends to ignore other (better) sources of fiber. The questionnaire used doesn't seem to exist anymore, so the cut off values used in this paper can't be verified. And without seeing the calculation methods for what constitutes too much fat, it's impossible to know if there was a reasonable cut-off or it if the questionnaire was the victim of low-fat dieting fads.
 
"They feed themselves on convenience food which needs minimal preparation, such as... ...fruit,..."

WTF is wrong with fruit? Especially whole, unprocessed fruit? I would have thought it was an ideal convenience food.
 
Sean said:
"They feed themselves on convenience food which needs minimal preparation, such as... ...fruit,..."

WTF is wrong with fruit? Especially whole, unprocessed fruit? I would have thought it was an ideal convenience food.
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Me too - fruit, nuts, simple bits of salad, natural soya or coconut yoghurt, eggs, fish, chicken cooked plain and simply without anything added - staple foods for me.
 
Sean said:
"They feed themselves on convenience food which needs minimal preparation, such as... ...fruit,..."

WTF is wrong with fruit? Especially whole, unprocessed fruit? I would have thought it was an ideal convenience food.
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Fructose is the one sugar that's not used by cells for energy : it' s dumped in the liver and can contribute to non alcoholic fatty liver disease - explanation below
https://www.dietdoctor.com/fructose-fatty-liver-sugar-toxin
 
Amw66 said:
Fructose is the one sugar that's not used by cells for energy : it' s dumped in the liver and can contribute to non alcoholic fatty liver disease - explanation below
https://www.dietdoctor.com/fructose-fatty-liver-sugar-toxin
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That didn't sound right to me, so I did a bit of digging and found this paper which shows that fructose is metabolised for energy production:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3533803/
Summary
Figure  3 summarizes the major metabolic fates of dietary fructose based on the data obtained from the reviewed isotope tracer studies. The mean oxidation rate of dietary fructose was 45.0% (ranged 30.5-59%) of ingested doses in normal subjects within a period of 3–6 hours. With exercise conditions, the mean oxidation rate of fructose came to 45.8% (ranged 37.5-62%) within 2–3 hours. When fructose was ingested together with glucose, the mean oxidation rate of the mixed sugars increased to 66.0% (ranged 52.2-73.6%) under similar exercise conditions. Secondly, the mean conversion rate from fructose to glucose was 41% (ranged 29-54%) of ingested dose in 3–6 hours after ingestion in normal non-exercise subjects. This value may be higher in subjects under exercise. The conversion amount from fructose to glycogen remains to be further clarified. Thirdly, at short time periods (≤ 6 hours), it appeared that only a small percent of fructose carbons enter the pathway of liponeogenesis after fructose ingestion. The hyperlipidemic effect of dietary fructose observed in both tracer and non-tracer studies may involve other metabolic mechanisms and this could relate to energy source shifting and lipid sparing. Lastly, fructose can be catabolized into lactate and cause an increase of blood lactate concentrations. Approximately a quarter of ingested fructose could be converted into lactate within a few of hours and this is a means to release fructose-derived carbons from the liver for extrahepatic utilization. Even though the reviewed tracer studies may not be fully representative of real-life diets and the obtained data are limited, this review provides a basic outline how fructose is utilized after it is consumed by humans.
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Trish said:
That didn't sound right to me, so I did a bit of digging and found this paper which shows that fructose is metabolised for energy production:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3533803/
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Interesting
I' d looked at fructose due to the role it plays in both NAFLD and insulin resistance with more of a molecular overview. The deciding factor is probably the amount ( i eat a lot of fruit and always have ) ie what is " chronic" fructose consumption .

This was a reference i' d looked at and bookmarked previously
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5372893/

Sorry on my phone and can' t cut and paste the actual body of text.
Both are interesting.
 
And don't forget that all of us, sick and well alike, must have as a bare minimum so that we can all live to our full potential, the Basic Package. This absolutely "essential part of life" starter kit consists of
  • Multi-vitamin - one daily;
  • Multi-mineral Mix - 2-3 grams daily;
  • Hemp oil - one tablespoonful daily;
  • Vitamin C - 2 grams at night.
and will only set you back a tiny £90. To be fair, some of these will last more than a month. What's more, they are available at Dr. Myhill's own shop! Oh, and don't forget to get all your amalgam fillings removed and have a good old detox while you're at it. If you haven't found the "key" to your recovery yet, just keep spending, people; it's bound to be hiding somewhere under a pile of junk.

Aha!! I knew the "key" was in an alternative bottle somewhereupload_2018-3-13_13-6-17.jpeg
 
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