I’ve been on several of those!
Risperidone did nothing except give me brain fog.
Latuda works great for OCD (what I take it for), but if it has any impact on ME, it’s marginal. I thought it had some minor benefit when I started it, but it’s very possible it was just the downstream effect of not being extremely stressed from OCD all the time.
Methylphenidate has been very helpful with brain fog, avoiding cognitive PEM, and OI, but it doesn’t seem to get at the core of ME. The improvements in brain fog and cognitive PEM threshold may just be because I have ADHD, so the drug probably reduces how much effort it is to concentrate. I’m not sure whether it would help someone who doesn’t have ADHD.