Fatigue in Epstein-Barr virus infected adolescents and healthy controls: A prospective multifactorial association study (2019) Wyller et al.

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https://www.sciencedirect.com/science/article/pii/S0022399918309462

Journal of Psychosomatic Research
Available online 10 April 2019
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Fatigue in Epstein-Barr virus infected adolescents and healthy controls: A prospective multifactorial association study
Author links open overlay panelMariaPedersen
Tarjei TørreAsprustenKristinGodangTruls MichaelLeegaardLiv TorilOsnesEvaSkovlundTrygveTjadeMerete GlenneØieVegard Bruun BratholmWyller
https://doi.org/10.1016/j.jpsychores.2019.04.008Get rights and content

Highlights


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Fatigue, no matter the cause, is highly associated with quality of life and negative emotions.

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Even in acute EBV infection, the associations between fatigue and immune response markers were sparse.

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Associations between cognition and fatigue shifted from positive during acute EBV infection to negative six months later.

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Autonomic alterations were exclusively associated to fatigue long after infection.



Abstract
Objective
Acute Epstein-Barr virus (EBV) infection is a known trigger of both acute and chronic fatigue. The aim of this study was to investigate associations to fatigue in adolescents with EBV infection during the initial stage and six months after, as well as in healthy controls.

Methods
200 adolescents (12–20 years old) with EBV infection were assessed as soon as possible after the onset of symptoms (EBVbaseline) and six months later (EBVsix months, 5 drop-outs). Also, 70 healthy controls (HC) were included. Associations between current fatigue and 148 different variables (including symptoms, functional abilities and biomarkers) were investigated separately for EBVbaseline, EBVsix months and HC using linear regression modelling.

Results
Fatigue was associated with symptoms of sleeping difficulties, negative emotions, and quality of life under all circumstances. Fatigue was independently associated with markers of immune response at EBVsix months and in HC, not at EBVbaseline. An association between fatigue and markers of autonomic cardiovascular control was only present at EBVsix months. Cognitive functioning shifted from a positive association to fatigue at EBVbaseline to a negative trend at EBVsix months. Markers of infection were not associated with fatigue at EBVbaseline, EBVsix months nor in HC.

Conclusion
Irrespective of the cause, fatigue is important for quality of life and is highly associated with negative emotions. Markers of infection and immune response had respectively none and barely any association to fatigue. Autonomic alterations and cognitive dysfunction were exclusively associated with fatigue long after infection, corroborating findings from studies of the Chronic Fatigue Syndrome.

Keywords
Adolescents
Epstein-Barr virus infection
Fatigue
Chronic fatigue

© 2019 Published by Elsevier Inc.
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There's some interesting data here. They've effectively done a linear regression analysis for a huge number of variables against fatigue as the dependent variable (dependent in a mathematical sense, though as it appears in a journal on psychosomatic research it's probably fair to assume the authors do view fatigue as being dependent on negative emotions rather than the other way around).
 
Did Klimas or Hanson not do an adolescent EBV study over a longer timeframe with Gordon Broderick doing the " fancypant" maths?

It might be interesting to compare immune markers etc.

Too late for me to try and get my head around anything tonight.
 
Londinium said:
There's some interesting data here. They've effectively done a linear regression analysis for a huge number of variables against fatigue as the dependent variable (dependent in a mathematical sense, though as it appears in a journal on psychosomatic research it's probably fair to assume the authors do view fatigue as being dependent on negative emotions rather than the other way around).
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Clearly, hunger causes lack of food.

I really need to work on establishing my tiger-repelling rock business. That stuff just works: no tigers anywhere!
 
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