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Ganglionic Acetylcholine Receptor Antibodies in Postural Tachycardia Syndrome. Bryarly et al. 8/2021

Discussion in 'Other Health News and Research' started by voner, Sep 7, 2021.

  1. voner

    voner Senior Member (Voting Rights)



    Objective: Postural tachycardia syndrome (POTS), the most common form of dysautonomia, may be associated with autoimmunity in some cases. Autoantibodies against the ganglionic acetylcholine receptor (gAChR) have been reported in a minority of patients with POTS, but the prevalence and clinical relevance is unclear.

    Methods: Clinical information and serum samples were systematically collected from participants with POTS and healthy control volunteers (n = 294). The level of positive gAChR antibodies was classified as very low (0.02-0.05 nmol/L), low (0.05-0.2 nmol/L), and high (>0.2 nmol/L).

    Results: Fifteen of 217 patients with POTS (7%) had gAChR antibodies (8 very low and 7 low). Six of the 77 healthy controls (8%) were positive (3 very low and 3 low). There were no clinical differences between seropositive and seronegative patients with POTS.

    Conclusions: Prevalence of gAChR antibody did not differ between POTS and healthy controls, and none had high antibody levels. Patients with POTS were not clinically different based on seropositivity. Low levels of gAChR antibodies are not clinically important in POTS.

    this article appears to be behind a pay wall.
    Last edited by a moderator: Sep 8, 2021
  2. Hutan

    Hutan Moderator Staff Member

    New Zealand
    Great to see a negative result from a good sized study being published.
    (edit: I mean, ... and the negative result being clearly presented in the abstract, rather than spun as a positive result.)
    Last edited: Sep 8, 2021
    alktipping, voner, Mij and 12 others like this.

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