autoimmunity

Sex and disease differences in patients’ diagnostic experiences in autoimmune diseases: an international cross-sectional study Summary Background Females have higher rates of autoimmune disease and reported misdiagnoses. Our study uses patient-reported diagnostic data to capture, and compare...

Exploratory clinical and immunological changes following Tixagevimab/Cilgavimab administration in immunodeficient patients with SARS-CoV-2-associated ME/CFS and persistent circulating spike protein Seidel; Anft; Wiemers; Seibert; Bertram; Rosiewicz; Stervbo; Westhoff; Babel BACKGROUND...

Impaired control of autoimmunity increases pediatric multiple sclerosis risk in EBNA-1-seropositives and -seronegatives Abstract Multiple sclerosis (MS) is an autoinflammatory disease of the central nervous system (CNS). Epstein–Barr virus (EBV) encodes for EBNA-1 381-452 , which induces...

A pro-inflammatory effector-memory T cell program links peripheral EBV priming to CNS autoimmunity Abstract T and B cell-mediated immunosurveillance of the central nervous system (CNS) can become maladaptive in multiple sclerosis (MS). Epstein-Barr virus (EBV) is a likely driver of MS, yet...

Intestinal flagellin drives multisystem inflammation through TLR5-IL-15-ARA axis BACKGROUND Systemic inflammatory diseases including rheumatoid arthritis (RA), ankylosing spondylitis (AS), IBD and long covid share convergent multi-organ phenotypes. Long covid provides a tractable model for...

EBV Reprograms B Cells in an Autoimmune-Like Fashion in Patients with COVID-19 Epstein-Barr virus (EBV) reprograms B cells in autoimmune disease. Reprogrammed EBV+ B cells activate nearby B and CD4+ T cells, via upregulated antigen presentation and costimulatory machinery, to drive autoimmune...

Emerging trends in post-COVID immune dysregulation: a narrative review Abstract Background: Long coronavirus disease (COVID), or post-acute sequelae of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, is a multi-system condition associated with persistent immune...

Recent SARS-CoV-2 infections and increased antibody responses to viral antigens are associated with greater autoantibody reactivity BACKGROUND SARS-CoV-2-induced latent autoimmunity may play a role in long-COVID symptoms. This study explored associations between serum immunoglobulin G (IgG)...

Post-COVID-19 immune dysregulation and autoimmune sequelae Abdel-Moneim, Ahmed S.; Al-Balushi, Mohammad S.; Al-Jabri, Ali A. Highlights SARS-CoV-2 infection can induce persistent immune dysregulation : hyperinflammation, lymphopenia, and innate–adaptive imbalance. Molecular mimicry, bystander...

Immunoadsorption Versus Sham Treatment for Post-COVID Syndrome: A Randomised Sham-Controlled Crossover Trial BACKGROUND Post-Covid syndrome is a debilitating condition which may be caused and/or aggravated by autoantibodies. The current study aimed to determine whether autoantibody depletion...

Defective B cell tolerance in SLE lymph nodes underpins VH4-34 "clonal damnation" and PD-1+TOX+ autoreactive B cells expansion. Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease driven by uncensored B and T cell autoreactivity. Understanding this pathogenic process has been...

Differences in SARS-CoV-2 antigen persistence in individuals with systemic autoimmune rheumatic diseases compared to the general population: A RECOVER-Adult Cohort Study BACKGROUND Individuals with systemic autoimmune rheumatic diseases (SARDs) are at risk for worse acute and post-acute...

Microbiota-induced intestinal barrier disruption drives BAFF-mediated B-cell dysregulation and autoimmunity in long COVID Abstract Abstract Long COVID (post-coronavirus disease 2019 (COVID-19) condition) is an infection-associated chronic condition that can follow severe acute respiratory...

Now published, see post #3. Preprint: Abstract Background: Neurological Long COVID (n-LC) includes persistent cognitive and autonomic symptoms after SARS-CoV-2 infection. Prior studies of post-COVID conditions have described diverse humoral autoreactivity, but findings are heterogeneous, and...

Association of G-Protein-Coupled Receptors autoantibodies with vasoregulation in Post-COVID BACKGROUND The Post-COVID syndrome is associated with the generation of autoantibodies to vasoregulative G-protein coupled receptors (GPCR). It remains elusive, however, whether these autoantibodies...

Includes a long Covid subgroup with ME/CFS https://pmc.ncbi.nlm.nih.gov/articles/PMC12793287/ Open Forum Infect Dis . 2026 Jan 11;13(Suppl 1):ofaf695.1837. doi: 10.1093/ofid/ofaf695.1837 P-1662. Post-Acute Sequelae of COVID-19 and Post-COVID-19 Vaccination Syndrome: A Comparison of Clinical...

Journal of Clinical Medicine: Special Issue Deadline for manuscript submissions: 20 January 2026 Special Issue Information Dear Colleagues, Postural orthostatic tachycardia syndrome (POTS), myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and long COVID are complex syndromes caused...

Autoantibodies in long COVID in a black/mixed population compared with recovered and pre-pandemic controls INTRODUCTION Long COVID (LC), a clinical condition marked by persistent and new symptoms after infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), affects up to...

Autoimmune response to C9orf72 protein in amyotrophic lateral sclerosis Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by a progressive loss of motor neurons. Neuroinflammation is apparent in affected tissues, including increased T cell infiltration and...

Anti-neuronal and anti-mitochondrial autoantibodies are associated with lower functional status and more severe respiratory symptoms in post COVID syndrome Antje Vogelgesang, Anke Steinmetz, Angela Stufano, Valentina Schino, Domenico Plantone, Agnes Flöel, Guglielmo Lucchese [Line breaks...