Glutamate / glutamine / glutamic acid

[Saz94]

I keep seeing these terms come up, please could someone explain what these are.

For instance in Karl Morten's work he has found that glutamic acid is high in PWME but glutamine is low.

I know that glutamate is an excitatory neurotransmitter. Is that related too?

 

[InitialConditions]

I keep seeing these terms come up, please could someone explain what these are.

For instance in Karl Morten's work he has found that glutamic acid is high in PWME but glutamine is low.

I know that glutamate is an excitatory neurotransmitter. Is that related too?

Glutamate is indeed a neurotransmitter. Glutamine is a precursor to glutamate.

Glutamic acid is another amino acid. It serves as the precursor for the synthesis of GABA, which is the inhibitory correlate to excitory glutamate.

But glutamate is the metabolic precursor of GABA. It's all very complicated.

 

[lansbergen]

https://www.zora.uzh.ch/id/eprint/136313/1/PhD_Thesis_Despoina_Goniotaki.pdf

@InitialConditions

What do you make of this? Can we learn something from these people?

Aguzzi is a prion expert and looks further then the tip of his nose.

Weissman is one of the pioneers.

 

[mariovitali]

Glutamate metabolism may be a very important part of ME pathology and more specifically for the vicious cycle ME patients are experiencing.

 

[Midnattsol]

Glutamate is indeed a neurotransmitter. Glutamine is a precursor to glutamate.

Glutamic acid is another amino acid. It serves as the precursor for the synthesis of GABA, which is the inhibitory correlate to excitory glutamate.

But glutamate is the metabolic precursor of GABA. It's all very complicated.

Glutamate is the anion form of glutamic acid, while glutamine is glutamic acid + and extra NH3 group. They can be synthesized from eachother.

Excess glutamate is common in many chronic health conditions (also together with reduced glutathione). A decrease in glutamine is often seen together with inflammation (and hard physical activity), as glutamine can be used as fuel for immune cells.