Immune Correlates of Hyperglycemia and Vaccination in a Non-human Primate Model of Long-COVID, 2023, Palmer et al

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EndME

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Immune Correlates of Hyperglycemia and Vaccination in a Non-human Primate Model of Long-COVID

Abstract
Hyperglycemia, and exacerbation of pre-existing deficits in glucose metabolism, are major manifestations of the post-acute sequelae of SARS-CoV-2 (PASC). Our understanding of lasting glucometabolic disruptions after acute COVID-19 remains unclear due to the lack of animal models for metabolic PASC.

Here, we report a non-human primate model of metabolic PASC using SARS-CoV-2 infected African green monkeys (AGMs). Using this model, we have identified a dysregulated chemokine signature and hypersensitive T cell population during acute COVID-19 that correlates with elevated and persistent hyperglycemia four months post-infection. This persistent hyperglycemia correlates with elevated hepatic glycogen, but there was no evidence of long-term SARS-CoV-2 replication in the liver and pancreas. Finally, we report a favorable glycemic effect of the SARS-CoV-2 mRNA vaccine, administered on day 4 post-infection.

Together, these data suggest that the AGM metabolic PASC model exhibits important similarities to human metabolic PASC and can be utilized to assess therapeutic candidates to combat this syndrome.

Preprint: https://www.biorxiv.org/content/10.1101/2023.09.22.559019v1

Published version: https://www.nature.com/articles/s41467-024-50339-4
 
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"Hyperglycemia, and exacerbation of pre-existing deficits in glucose metabolism, are major manifestations of the post-acute sequelae of SARS-CoV-2 (PASC)." Apart from the Covid T2D link, I haven't seen evidence of this. But I suppose as long as Long Covid is very loosely defined one can almost claim anything.

This study also did an analysis of SARS-CoV-2 persistence in tissues 18 weeks post infection and the "data suggest no significant long-term persistence of replicating virus in the liver, pancreas or duodenum in our AGM PASC model".
 
Metabolic diseases, including type 2 diabetes (T2D)5, as well as conditions with less obvious metabolic undertones such as myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), thrombosis and neuropsychiatric sequelae (fog) embody the broad spectrum of long-COVID symptoms or PASC 1,6-10.
Click to expand...

They seem to be saying that their model is of 'metabolic PASC', so it's not of ME/CFS - Long Covid.
 
Not saying the above theory has any validity but presumably, if it were a common cause of ME/CFS, then UK GWAS (Chris Ponting - DecodeME) would turn up a genetic signal?
 
There seem to be new diabetics following COVID / vaccination.
When my mother in law was ill with diabetes complications earlier this year , I joined Diabetes UK 's community forum .
Whether people were prediabetic prior is not always known , but it does seem to be " a thing" .
 
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