Started to watch the first speaker but found all the general functional and integrative medicine stuff less than interesting.
Skipped forward to speaker #4 (
1:54:52) "
Travis Craddock, Ph.D. - Director of the Clinical Systems Biology Group The Potential Role of Ocular and Otolaryngological Mucus Proteins in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome".
Move over gut microbiome. Make way for the the nasal microbiome.
It appears chronic rhinitis is common in ME (I certainly have it but never really connected it to ME).
The team found a number of snps in mucus related genes. Referred to this study: Perez M, Jaundoo R, Hilton K, et al. Genetic Predisposition for Immune System, Hormone, and Metabolic Dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Pilot Study.
Front Pediatr. 2019;7:206. Published 2019 May 24. doi:10.3389/fped.2019.00206
Not sure if that is the much maligned Klimas 23andme study or a different one (
@wigglethemouse)? Either way, if I understood correctly, they looked at the data again and what's presented here is different from the data in the paper.
Their hypothesis, in my oversimplified words: disturbed nasal microbiome and/or lack of normal mucus protection leads to irritation of nasal cells which leads to immune response which can be propagated in the blood which leads to aggravation of ME symptoms elsewhere in the body. Alternatively irritants and pathogens can get directly into the brain via the nose if the mucus defenses are disrupted.
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