Preprint Investigating the Severity and Timeline of PASC Symptoms: Focus on Physiological and Cognitive Effects,

Investigating the Severity and Timeline of PASC Symptoms: Focus on Physiological and Cognitive Effects

Rohan Melwani, Keerthana Noru, Sanya Kondapalli, Ameya Ravi, Saanvi Shah, Shreeya Setty, Shashank Sastry, Sahar Jahanikia

[Preprint]

Abstract
The SARS-CoV-2 virus, responsible for the COVID-19 pandemic, has impacted the health of millions globally, with many individuals experiencing persistent symptoms even after testing negative, a condition known as Post-acute Sequelae of SARS-CoV-2 infection (PASC), or “Long COVID”.

This study analyzes demographic influences on the severity and timeline of PASC symptoms, with emphasis on physiological and cognitive effects. Using a self-reporting survey method, data was collected from a sample of 110 participants and analyzed using statistical methods such as Exploratory Factor Analysis (EFA), Pearson Correlation, and Two-Factor ANOVA Test. The participants were primarily based within California, and a majority of them were ethnically Asian.

Based on the study, females generally reported higher severity for cognitive and physiological symptoms compared to males, and symptom severity was generally lower among vaccinated individuals. Correlation analysis revealed a significant relationship between depression and cognitive impairments, underscoring the psychological impact of PASC.

This study emphasizes the complexity of PASC, demonstrating how demographic characteristics such as age, sex, and vaccination status influence the severity and duration of symptoms, contributing to the growing understanding of PASC. Further research should consider SARS-CoV-2 variant-specific impacts and broader population samples.

Link | PDF (Preprints.org)