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Is Gwibitang and its modification beneficial for alleviating symptoms in CFS: A systematic review and meta-analysis, 2020, Donghyun

Discussion in 'BioMedical ME/CFS Research' started by Dolphin, Jun 16, 2020.

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  1. Dolphin

    Dolphin Senior Member (Voting Rights)

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    https://www.koreascience.or.kr/article/JAKO202016357498272.page

    Free full text:

     
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  2. Peter Trewhitt

    Peter Trewhitt Senior Member (Voting Rights)

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    To those like me who had no idea what Gwibitang was, I just looked it up and it is a herbal formula used in traditional Korean medicine.

    Unfortunately the list of ingredients I found in a couple of academic papers meant nothing to me so I will not share links I found.
     
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  3. Trish

    Trish Moderator Staff Member

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    I see they accepted trials with subjective outcome measures. And the trials were described as randomised and controlled, but no mention in the abstract of being blinded. If not blinded, then they are all as useless as the CBT/GET trials.
     
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  4. rvallee

    rvallee Senior Member (Voting Rights)

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    When you have super high quality evidence.

    Could be ghosts. Could be cosmic wizards. Could be we are all dead and this is hell.

    If only there were some sort of process by which we can tell reliably whether something could be or not be. One that does not involve narratives and inventing entirely new words and meanings anyway.
     
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  5. Hutan

    Hutan Moderator Staff Member

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    Has a number of the usual components of tonics against fatigue

    And there could be something in that mix that is actually helping.

    Angelica gigas, - giant angelica
    Dimocarpus longan, - longan, a tropical fruit
    Zizyphus jujuba Miller (seed and fruit), - jujube in the buckthorn family
    Polygala tenuifolia, - yuan chi, a milkwort
    Panax ginseng, - Asian ginseng
    Astragalus membranaceus, - astralagus
    Atractylodes ovata, - atractylodes, a type of daisy
    Poria cocos, - Poria fungus
    Inula helenium, - Elecapane, a type of daisy
    Glycyrrhiza glabra, - Licorice root
    Zingiber officinale - ginger

    But it's impossible to know with unblinded studies. (I haven't seen an English version of the paper and I can't read Korean, but I'm willing to bet that among the studies included, there are some sponsored by companies selling Guibitang.)
    Yeah.
     
  6. Mithriel

    Mithriel Senior Member (Voting Rights)

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    Licorice raises blood pressure so it could be enough to reduce POTS
     
  7. Snow Leopard

    Snow Leopard Senior Member (Voting Rights)

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    Wow, it'd help if they isolated it down to one of those extracts. It's impossible to say what would be the relevant bioactive compound from that long list!
     
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  8. Mij

    Mij Senior Member (Voting Rights)

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    Panax ginseng, - Asian ginseng overstimulated my nervous system many years. I was jittery for 6 weeks until I realized it was the herb. Gave me insomnia too. I can't imagine all those herbs combined as beneficial for an already overactive nervous system.
     
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