1. Sign our petition calling on Cochrane to withdraw their review of Exercise Therapy for CFS here.
    Dismiss Notice
  2. Guest, the 'News in Brief' for the week beginning 15th April 2024 is here.
    Dismiss Notice
  3. Welcome! To read the Core Purpose and Values of our forum, click here.
    Dismiss Notice

Kynurenine pathway is altered in patients with SLE and associated with severe fatigue, 2018, Akesson et al.

Discussion in 'Other health news and research' started by Jaybee00, Oct 16, 2020.

Tags:
  1. Jaybee00

    Jaybee00 Senior Member (Voting Rights)

    Messages:
    1,894
    https://lupus.bmj.com/content/5/1/e000254


     
    Jaybee00, Oct 16, 2020
    #1
    MEMarge, Andy, adambeyoncelowe and 4 others like this.
  2. Trish

    Trish Moderator Staff Member

    Messages:
    52,310
    Location:
    UK
    Odd error. Niacin is Vitamin B3, not B12.
     
    Trish, Oct 16, 2020
    #2
    Mithriel, MEMarge, sebaaa and 9 others like this.
  3. Jaybee00

    Jaybee00 Senior Member (Voting Rights)

    Messages:
    1,894
    Jaybee00, Oct 16, 2020
    #3
    adambeyoncelowe, alktipping, TigerLilea and 3 others like this.
  4. Creekside

    Creekside Senior Member (Voting Rights)

    Messages:
    961
    The B12 = niacin error jumped out at me too. :) What was missing from the abstract is that they only measured serum and urine levels of metabolites. Since central fatigue is neurological, and many kynurenines don't cross the BBB easily, I consider their findings to be fairly useless. If they'd measured CSF levels, they might have gotten some interesting results. ME might involved fairly localized alterations in glial activity and kynurenine levels, so even a spinal tap may not reveal ME's secrets. I think some method of brain scanning for kynurenines may be needed.
     
    Creekside, Oct 16, 2020
    #4
    Mithriel, Kitty, MEMarge and 4 others like this.
  5. Andy

    Andy Committee Member

    Messages:
    21,947
    Location:
    Hampshire, UK
    Full abstract
     
    Andy, Oct 17, 2020
    #5
    Kitty, MEMarge, merylg and 1 other person like this.
  6. adambeyoncelowe

    adambeyoncelowe Senior Member (Voting Rights)

    Messages:
    2,732
    Kynurenine again! It's interesting how there was once a theory of too much serotonin causing fatigue in ME, and now it's an imbalance in the tryptophan/kynurenine pathway (both in ME and SLE).

    It's like the elephant in a dark room. Someone's feeling the trunk and thinks it's a snake. Maybe gradually, we can work out how all the bits fit together.
     
    adambeyoncelowe, Oct 17, 2020
    #6
    Kitty, MEMarge, sebaaa and 2 others like this.
  7. butter.

    butter. Senior Member (Voting Rights)

    Messages:
    200
    after 4 years in bed 100% I wish I was the elephant ...
     
    butter., Oct 17, 2020
    #7
    Snow Leopard, Kitty, MEMarge and 2 others like this.
  8. adambeyoncelowe

    adambeyoncelowe Senior Member (Voting Rights)

    Messages:
    2,732
    I'm not sure how to take that! :rofl:
     
    adambeyoncelowe, Oct 17, 2020
    #8
    Kitty, Trish and MEMarge like this.
  9. butter.

    butter. Senior Member (Voting Rights)

    Messages:
    200
    I did not want to go into the snake thing ...
     
    butter., Oct 17, 2020
    #9
    Kitty likes this.
  10. Kitty

    Kitty Senior Member (Voting Rights)

    Messages:
    5,388
    Location:
    UK
    It's interesting they appear to suggest that increased circulating levels of kynurenine could be linked to central fatigue, when the OMF trial is exploring the possibility of supplementing it...the objectives of the two studies may be different, though (I'm way out of my depth!)
     
    Kitty, Oct 17, 2020
    #10
    adambeyoncelowe, ukxmrv and Jaybee00 like this.

Share This Page