[ME/CFS Research Foundation] International ME/CFS Conference 2026 on 7–8 May - register for free now!

[V.R.T.]

I didn't manage to register for this but local UCL colleagues are attending.

I don't think we expected HLA genes to come up but I wonder why Chris seems to be suggesting that BTN2A1 is not immunological. Maybe it isn't but it seems likely on the face of it.

I didnt notice that on the slide. I think that's a bit of a sweeping statement, especially considering OLMF4 also has possible links to interferons.

But yes, I wonder why he's disregarded the BTN immune link in that manner.

 

[BrokenBeaktheBrave]

Disappointing about HLA! Did he mention the X chromosome analysis at all?

That it was ongoing.

I didn't manage to register for this but local UCL colleagues are attending.

I don't think we expected HLA genes to come up but I wonder why Chris seems to be suggesting that BTN2A1 is not immunological. Maybe it isn't but it seems likely on the face of it.

I registered halfway through the morning session and was sent a link to the webinar immediately. Took a less than a minute to register. Link if anyone wants it:

https://cloud.seatable.io/dtable/forms/c9d4df0e-275a-4bb4-9996-dd0f0ec14a18/

 

[ME/CFS Science Blog]

I don't think we expected HLA genes to come up but I wonder why Chris seems to be suggesting that BTN2A1 is not immunological. Maybe it isn't but it seems likely on the face of it.

Perhaps it's just that DecodeME on its own didn't have the precision to pinpoint BTN2A1, it's only with the DecodeME PheWAS of rare variants that it became a likely candidate. He talked about BTN2A1 during the presentation.

 

[Jonathan Edwards]

Perhaps it's just that DecodeME on its own didn't have the precision to pinpoint BTN2A1, it's only with the DecodeME PheWAS of rare variants that it became a likely candidate. He talked about BTN2A1 during the presentation.

But DecodeME came up with the BTN region which is just as immunological.
I don't think it matters much.

 

[Chandelier]

Those of us who block trackers on our computers/phones can't see tweets - we either get blank space or an error message. So it would be really useful and appreciated if the text of tweets could be copied and pasted into posts. Sorry for the extra work!

I second that.
Copying the content into the post also makes sense from an archival point of view.
If Elon abandons Twitter or if one of its competitors goes bankrupt, it will be hard to follow old discussions.

 

[salin]

Those of us who block trackers on our computers/phones can't see tweets - we either get blank space or an error message. So it would be really useful and appreciated if the text of tweets could be copied and pasted into posts. Sorry for the extra work!

Sorry I can't do that - but this links should work with blocked trackers:

https://xcancel.com/grandebettina/status/2052299165036671236?s=46

https://xcancel.com/mecfsskeptic

 

[Eleanor]

Sorry I can't do that - but this links should work with blocked trackers:

https://xcancel.com/grandebettina/status/2052299165036671236?s=46

https://xcancel.com/mecfsskeptic

That's great, thank you

 

[ryanc97]

The Dara trial should have like maybe 20 patients at the 4 month mark assuming they administered the Dara in January.

 

[V.R.T.]

This post about Seiferts talk mentions a finding of CD24 in extracellular vessicles.

Could this connect to Mensa/Armstrong/Cambridge's finding of increased cd24 (and cd38)

IIrc @Jonathan Edwards said Jo C thinks CD24 is important in MECFS.

 

[ryanc97]

Autoabs in the brain

 

[ryanc97]

Very blurry and laggy stream

 

[ryanc97]

Leets hope they sort out the blurry and lag before Fluge presents tmrw

 

[MelbME]

This post about Seiferts talk mentions a finding of CD24 in extracellular vessicles.

Could this connect to Mensa/Armstrong/Cambridge's finding of increased cd24 (and cd38)

IIrc @Jonathan Edwards said Jo C thinks CD24 is important in MECFS.

Yeah I will follow up with them. Seems they have overlooked the cd24 b cell connection.

 

[Jaybee00]

Very blurry and laggy stream

Stream fine for me—must be the aabs in the brain….

 

[neophyte32]

Thanks for the feedback on the conference.
Excuse my lack of scientific knowledge, but many people on Twitter are worried because this imaging might have shown problems with the bone marrow.
Why is this so serious?
It's not an area that's easily treated or explored, is it?

 

[ME/CFS Science Blog]

Yeah I will follow up with them. Seems they have overlooked the cd24 b cell connection.

Don't forget that you're presenting in a couple of minutes!

 

[ryanc97]

Thanks for the feedback on the conference.
Excuse my lack of scientific knowledge, but many people on Twitter are worried because this imaging might have shown problems with the bone marrow.
Why is this so serious?
It's not an area that's easily treated or explored, is it?

Pesky bad LLPCs in the bone marrow? Idk if that’s how it works lol

 

[V.R.T.]

Yeah I will follow up with them. Seems they have overlooked the cd24 b cell connection.

Thanks for doing that! Its an interesting connection to your study, perhaps it will lead somewhere!

 

[ChronicallyOverIt]

Weren’t these presented a while ago and the paper didn’t fully come out? I can’t watch the stream, did they present more data than last time or update when the full paper will be available?

 

[Utsikt]

Weren’t these presented a while ago and the paper didn’t fully come out? I can’t watch the stream, did they present more data than last time or update when the full paper will be available?

A previous presentation was discussed here:

'Community Symposium on the Molecular Basis of ME/CFS Sept 5 (Stanford/Ron Davis)'
https://www.s4me.info/threads/commu...s-sept-5-stanford-ron-davis.45671/post-639451