Mitochondrial alterations in NK lymphocytes from ME/CFS patients, 2019, Silvestre et al

Andy · Jul 14, 2019

Abstract only, from "Immunology 2019™ Meeting Abstracts"

Abstract
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a disease characterized by profound fatigue, flu-like symptoms, trouble concentrating, and autonomic problems, all of which worsen after exertion. ME/CFS patients have impaired natural killer (NK) cell activity. NK lymphocytes are a critical first defense against viruses and cancer. ME/CFS patients have difficulties controlling viral infections and many develop non-Hodgkin’s lymphoma. Mitochondrial metabolism is crucial for immune cell function. Mitochondria dysfunction has been previously reported in ME/CFS, but it is not known whether the NK cells of these patients have altered mitochondrial metabolism that affect their activity and contribute to ME/CFS pathogenesis. More importantly, there is currently no efficient method to diagnose ME/CFS or assess efficacy of therapeutic interventions. The Bioenergetic Health Index (BHI) has been developed as promising and reliable surrogate readout of human health by measuring the bioenergetic status of immune cells. Variations in bioenergetic function in patient’s immune cells can reflect both metabolic stress and the mutable role of these cells in ME/CFS immunity and pathogenesis.

In our study, we observed that the two main energy-generating mitochondrial pathways, oxidative phosphorylation and glycolysis (bioenergetics parameters), are deregulated in ME/CFS NK cells and in PBMCs. Moreover, we observed alterations in the morphology and membrane potential of the mitochondria of NK cells. These mitochondrial features can affect NK cell function and contribute to the severity of disease. To date, this is the first metabolism assessment of NK cells in ME/CFS and as potential new diagnostic tool for the disease.
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www.jimmunol.org/content/202/1_Supplement/126.39

sb4 · Jul 14, 2019

"ME/CFS patients have difficulties controlling viral infections and many develop non-Hodgkin’s lymphoma."

Does it say in the full text how many develop lymphoma?

Trish · Jul 14, 2019

Being a meeting abstract, there may not be a full paper published yet. I tried Sci-hub and it just gave the abstract.

Mithriel · Jul 14, 2019

An unexpectedly high number of victims of the Lake Tahoe outbreak developed non- Hodgkins lymphoma. That was the reason they investigated XMRV.

if I remember rightly, it was the ones who were positive for EBV during the outbreak who were most likely to become ill.

Whether it is common in the general ME population is another question.

Ravn · Jul 14, 2019

Not sure if there's any link to the current paper but the team involved received a Ramsay Award in 2016.
https://solvecfs.org/2016-ramsay-award-program-results/

Here is more about their Ramsay project; like the abstract posted above by @Andy it relates to the 'bioenergetic health index".
https://solvecfs.org/the-bioenerget...diagnostic-tool-for-chronic-fatigue-syndrome/

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Mitochondrial alterations in NK lymphocytes from ME/CFS patients, 2019, Silvestre et al

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