News from PrecisionLife Ltd.

Andy said:
Tweet from PrecisionLife

"We're delighted to share the progress being made in the #MetX research study. PrecisionLife and @MetrodoraInst have begun sharing the first results with #MECFS and #LongCOVID participants - bridging from Biobank Analysis to Bedside in record time.

https://precisionlife.com/news-and-...e-first-insights-with-metx-study-participants"
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From link to "More about our ME/CFS research" at the bottom:

"In over 30 years of global research into the disease, not a single replicable genetic finding had been reported until now.

We have for the first time identified some of the different genetic mechanisms causing ME/CFS and used this to stratify patients.

We’re currently replicating our results in a much larger, better characterized patient population, using thee DecodeME study data as part of the LOCOME (Long Covid and ME) grant supported by Innovate UK.

PrecisionLife is now conducting research to:
  1. Validate simple saliva/blood genotyping tests for ME/CFS and long COVID
  2. Identify actively protective biology that may prevent people getting ME or help them to recover
  3. Identify and validate drug repurposing candidates that may be able to treat ME patients
Here, we've collated links to papers, posters, videos and blogs, about our recent ME/CFS and long COVID research."

Papers they cite (links to threads):

Genetic Risk Factors for ME/CFS Identified using Combinatorial Analysis, 2022, Das et al

Genetic Risk Factors for Severe and Fatigue Dominant Long COVID and Commonalities with ME/CFS Identified by Combinatorial Analysis, 2023, Taylor et al

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PrecisionLife and Metrodora Foundation announce confirmation of key genetic findings for long COVID across diverse populations

Results reproduce PrecisionLife’s previously identified long COVID genetic associations to provide compelling evidence for new precision diagnostics and treatments

OXFORD, UK and SALT LAKE CITY, UT – 26 February 2025
  • 45 out of 51 (88%) of genes identified by PrecisionLife in its previous UK study were confirmed to also be associated with long COVID in an independent US cohort
  • 11 out of 13 genes for which drug repurposing candidates have been identified were reproduced, encouraging their rapid validation in clinical trials
  • The findings highlight the biology underlying long COVID, with potential for refining diagnostic criteria, the discovery of more accurate diagnostic tools, and exploring therapeutic targets for long COVID, ME/CFS and related chronic conditions.
  • Demonstrates the unique capability of AI-led combinatorial analytics for understanding the genetic mechanisms underpinning complex diseases affecting multiple systems in the body
LINK
 
Just wanted to highlight this document where Precision Life outline their plans regarding clinical trials and next steps. It seems extremely optimistic and obviously they are a business, but it's the clearest explanation of what they plan that I've found.

The stuff about protective biology is particularly intriguing...

Really interested to see if their findings replicate in DecodeME

https://precisionlife.com/hubfs/Lon...by PrecisionLife.pdf?hsCtaAttrib=186733826981
 
Looks like they have already replicated some results using at least some of the DecodeME data.
Building on these encouraging initial findings, we applied for and won funding from Innovate UK for the LOCOME project, which kicked off in December 2023. Led by PrecisionLife, with Prof. Chris Ponting’s group at University of Edinburgh, and Action for ME as partners, this project was designed to confirm the earlier UK Biobank findings using DecodeME (https://www.decodeme.org.uk), the world’s largest ME/CFS study, and other global data sources. We’ve since replicated many of the findings of the original study in the first batches of DecodeME data, and are working with the DecodeME team to complete and publish the results of this work.
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V.R.T. said:
Just wanted to highlight this document where Precision Life outline their plans regarding clinical trials and next steps. It seems extremely optimistic and obviously they are a business, but it's the clearest explanation of what they plan that I've found.
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Ooh...

PrecisionLife said:
We’ve had some very encouraging results from the first year of studying the genetics of people with these diseases:

  • We found 14 novel genes in ME/CFS and 73 in long COVID, many of which we also found in separate patient populations including the UK DecodeME and the US All of Us cohorts.
  • We’ve identified 9 safe generic drugs that we hope to prove may benefit patients in both diseases – like the COVID-19 RECOVERY repurposing trial but with genetic evidence.
  • We found 9 genes we believe may protect against the onset / progression of the diseases.
  • We’re turning these insights into a new class of rapid, non-invasive diagnostic tests.
  • We’re running clinical trials in the US, recruiting 1,000 ME and long COVID patients to clinically validate these new diagnostic & therapeutic options.
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We found 14 novel genes in ME/CFS and 73 in long COVID, many of which we also found in separate patient populations including the UK DecodeME and the US All of Us cohorts.​

Interesting.

At first glance it seems to suggest considerable difference between LC and ME/CFS. But I wonder what will happen to those numbers for LC over much longer time frames (i.e. decades of having LC). Specifically, will they fall to nearer the ME/CFS numbers?
 
It also says on the information about the MELO study page

'This is a low-risk study with no intervention or treatment. Sample collection, using a cheek swab, involves minimal to no physical risk and no research related injuries are expected.'

Which is interesting considering they are talking about it elsewhere like participants will be given one of these 9 drugs as part of the study. But perhaps thats like part 2 after they validate the diagnostic.

It's all a bit vague.


P.s. don't know how to make text into the yellow quotes if not quoting direct from forum haha
 
Jaybee00 said:
Spill the beans on the 9 drugs!?

The fact that they say the nine drugs are safe is not encouraging.

If they said it was something dangerous like this https://en.wikipedia.org/wiki/Melarsoprol, I’d be more inclined to believe it.

I’m only being partially facetious.
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I know what you mean! I sort of feel like that but perhaps it is an irrational feeling?

Plus safe is a relative term in medical drug lexicon. A lot of stuff can be 'safe' but have quite unpleasant side effects.
 
V.R.T. said:
P.s. don't know how to make text into the yellow quotes if not quoting direct from forum haha
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Select the text, then press the button highlighted below, then "Quote" in the dropdown. Or press the button first, and paste the text in between the [ QUOTE] and [ /QUOTE]
Screenshot_20250308-115058.png Screenshot_20250308-115125.png
 
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