Precision medicine for chronic diseases
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Tweet from PrecisionLife
"We're delighted to share the progress being made in the #MetX research study. PrecisionLife and @MetrodoraInst have begun sharing the first results with #MECFS and #LongCOVID participants - bridging from Biobank Analysis to Bedside in record time.
https://precisionlife.com/news-and-...e-first-insights-with-metx-study-participants"
Building on these encouraging initial findings, we applied for and won funding from Innovate UK for the LOCOME project, which kicked off in December 2023. Led by PrecisionLife, with Prof. Chris Ponting’s group at University of Edinburgh, and Action for ME as partners, this project was designed to confirm the earlier UK Biobank findings using DecodeME (https://www.decodeme.org.uk), the world’s largest ME/CFS study, and other global data sources. We’ve since replicated many of the findings of the original study in the first batches of DecodeME data, and are working with the DecodeME team to complete and publish the results of this work.
Just wanted to highlight this document where Precision Life outline their plans regarding clinical trials and next steps. It seems extremely optimistic and obviously they are a business, but it's the clearest explanation of what they plan that I've found.
PrecisionLife said:We’ve had some very encouraging results from the first year of studying the genetics of people with these diseases:
- We found 14 novel genes in ME/CFS and 73 in long COVID, many of which we also found in separate patient populations including the UK DecodeME and the US All of Us cohorts.
- We’ve identified 9 safe generic drugs that we hope to prove may benefit patients in both diseases – like the COVID-19 RECOVERY repurposing trial but with genetic evidence.
- We found 9 genes we believe may protect against the onset / progression of the diseases.
- We’re turning these insights into a new class of rapid, non-invasive diagnostic tests.
- We’re running clinical trials in the US, recruiting 1,000 ME and long COVID patients to clinically validate these new diagnostic & therapeutic options.
Looks like they have already replicated some results using at least some of the DecodeME data.
Anyone has any idea where we could find information about these clinical trials?
Spill the beans on the 9 drugs!?
The fact that they say the nine drugs are safe is not encouraging.
If they said it was something dangerous like this https://en.wikipedia.org/wiki/Melarsoprol, I’d be more inclined to believe it.
I’m only being partially facetious.