News from the USA, United States of America

Mij said:
Tim Hendrich's team is using multimodal PET imaging to measure T cell activation post-COVID: "We saw significant increases in activated T-cell signalling in [the brain stem and spinal cord], that shouldn't have activated T-cells in them."
https://twitter.com/user/status/1849512012683894875
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https://twitter.com/user/status/1849512015020052776

"Dr. Hendrich will present more findings from his #LongCovid PET and biopsy study at PolyBio’s upcoming symposium:"

Zoom link (Nov 8, 2024, 4:00 PM GMT)
 
University of South Florida: “USF Health receives $3.75 million NIH award to research whether Long COVID may contribute to Alzheimer’s disease and dementia”

“The grant, awarded in September, funds a five-year investigation with the potential for broad impact, given COVID-19 has burdened an estimated 30 million Americans with neurologic symptoms..”

“This NIH RO1 award has the potential to significantly impact our understanding of the long-term adverse effects of COVID, provide new insights into the triggers of dementia and eventually help the patients we serve,” he said.

“.. the public health impact is profound due to the number of individuals of all ages who have been or will be infected. There is a great lack of knowledge of the basic neuropathology and how to treat or prevent these conditions.”

“These include dementias and a drop in global cognitive performance,” Dr. Mohapatra said

"In a series of studies, they found that Long COVID produces a marker for Alzheimer’s disease called tau – an accumulation of neurotoxic molecules that create aggregates known as tauopathy. This accumulation leads to memory loss and loss of cognition, the hallmarks of Alzheimer’s. Autopsies of individuals suffering from these symptoms revealed evidence that the virus made its way into the brain through inflammation to cause neurological issues."

'Autopsies of individuals suffering from these symptoms revealed evidence that the virus made its way into the brain through inflammation to cause neurological issues.”

“The team aims to understand the cellular and molecular mechanisms behind COVID-induced tauopathy and identify potential drug targets to prevent or slow its progression.”

“Our model suggested that it can cause neuroinflammation – that was very important, because any neurodegenerative disease begins with this inflammation.”

“Four years later, they are truly taking their research to an even higher level – fueled by a landmark grant that underscores the vital importance of their work.”
 
There are quite a few studies lately showing that shingles may increase the risk of cognitive decline and AD. It's important to study the role of viral infections and cognitive impairment.
 
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Dakota15 said:
In a series of studies, they found that Long COVID produces a marker for Alzheimer’s disease called tau – an accumulation of neurotoxic molecules that create aggregates known as tauopathy.
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Anyone know which studies they're referring to?
 
NelliePledge said:
I don’t understand why people keep announcing that viruses have long term effects as some kind of revelation.
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It is definitely news to about 99% of MDs. Even those who "know" it. They don't actually know it, only some version of it that isn't especially close to reality.

It will have to be repeated until it sinks in, which at the rate things are going might be a long while. I'm glad it is. It should be repeated more. Louder. Happier. With mouths way more open. (Link is to a hilarious comedy sketch, if you're well and in the mood to laugh)
 
Using the latest tools in genetic sequencing, researchers at Mayo Clinic reconstructed how a collective of viral genomes colonized a human brain. The virus acquired distinct mutations that drove the spread of the virus from the frontal cortex outward throughout the brain.
"Our study provides compelling data that shows how viral RNA mutated and spread throughout a human organ — the brain, in this case," says virologist Roberto Cattaneo, Ph.D., who is a co-lead author on the new study, published in PLOS Pathogens. "Our discoveries will help studying and understanding how other viruses persist and adapt to the human brain, causing disease. This knowledge may facilitate the generation of effective antiviral drugs."

Dr. Cattaneo and his team had this unique research opportunity through a collaboration with the Centers for Disease Control and Prevention (CDC). They studied the brain of a person who had contracted measles as a child and had succumbed to a rare, lethal brain disease called subacute sclerosing panencephalitis (SSPE) years later as an adult. They investigated 15 specimens from different regions of the brain and conducted genetic sequencing on each region to piece together the puzzle of how the measles virus mutated and spread
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LINK
 
Yale Medicine: 'Listening to Patients: Improving Care for Long COVID and Other Conditions'

“Chronic post-viral syndromes are common for a host of other viral conditions,” she says, “and we haven’t been paying enough attention to any of them," says Dr. Spatz

'Post-viral syndromes, including Long COVID, likely have a variety of physical causes. More multi-disciplinary research—involving scientists, therapists, and diagnosticians alike—is needed for these types of chronic conditions, the researchers say.'

'..patient-centric approach could benefit not only those with Long COVID, but also many people who already live with other poorly understood chronic syndromes.'
 
10/21/24: 'CDC Provides Supplemental Award to CMSS to Improve Provider Education and Engagement to Care for People with Long COVID'

'In partnership with the Department of Health and Human Services’ Office of Long COVID Research and Practice (OLC), the Centers for Disease Control and Prevention (CDC) recently awarded supplemental funding via a cooperative agreement to the Council of Medical Specialty Societies (CMSS). The funding will support CMSS to provide multidisciplinary coordination and collaboration across medical societies to improve provider education and engagement in the care of patients with Long COVID.'

“CMSS is pleased to support this timely and important work on Long COVID,” said Helen Burstin...
 
9/10/24, SELF: 'Here’s Where Kamala Harris Stands on 6 Essential Health Issues'

'Also worth noting: The Biden-Harris administration has launched a response to long COVID, specifically funneling resources toward research, as well as expanding care for folks with the condition and education for medical providers. That said, advocates have since pointed to a lack of social recognition for the condition and a drop-off in funding for it in Biden’s budget request for the National Institutes of Health in 2025—and it’s not clear if Harris plans to address either concern.'
 
1. 12/27/23, Conversations on Health Care: "Long COVID: 2023’s Enduring Medical Mystery"

“..individuals with long COVID, if they try to push themselves too hard and just grit their teeth..their bodies just crash..their symptoms get worse...”

2. 9/27/23, Conversations on Health Care: 'NYT’s Diagnosis Columnist Dr. Lisa Sanders’ (Yale) Views on Long COVID Affirmed by New Research'

LS: “Fatigue, brain fog….probably the two most common problems I see…people get dizzy when they stand up…tachycardia”

3. 7/18/23, Conversations on Health Care: 'Latest on Long COVID: NIH Study Leader Leora Horwitz'

LH: “The amount of information & data…that we've collected..spectacularly fast. I cannot think of another study that has happened that fast & with that speed”

“One of the most amazing things I think about this pandemic is the degree to which patients themselves have self-organized and have provided that kind of knowledge and support that honestly was really missing in the medical community. Much of what we knew early on and still to this day, what we know comes from patient groups and patient advocacy organizations.”
 
PolyBio supports & helps conceptualize long Covid rapamycin clinical trial

The trial will test a low dose of the drug rapamycin in participants across a 3-month period. Analysis of participant blood samples will determine if rapamycin improves components of the immune response that can control infection.

Medford MA, October 30, 2024 – PolyBio Research Foundation is excited to announce an $800,000 donation to the Icahn School of Medicine at Mount Sinai to support a clinical trial of the drug rapamycin in patients with long COVID. The trial will be conducted at CoRE: a clinic directed by Dr. David Putrino and PolyBio’s Dr. Amy Proal.

LINK
 
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