Opposite white matter abnormalities in post-infectious vs. gradual onset chronic fatigue syndrome revealed by diffusion MRI, 2024, Yu et al

The distinct WM impairments between the PI-ME/CFS and GO-ME/CFS groups highlight the heterogeneity of ME/CFS. Interestingly, conventional clinical measures (SF-36, HADS, PSQI and BDS) did not differentiate between the two groups. This discrepancy calls into question the effectiveness of current clinical assessment tools for distinguishing ME/CFS subgroups and highlights the need for more sensitive instruments.
 
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