Dolphin
Senior Member (Voting Rights)
ME Association Facebook:
Research: Does poor oxygenation and a delay in muscle energy recovery contribute to fatigue and PEM in ME/CFS? Now Recruiting!
The ME Association is supporting Stage 1 of a University of Oxford study investigating whether impaired muscle oxygenation and delayed energy recovery contribute to fatigue and post-exertional malaise (PEM) in ME/CFS.
Led by Professor Ladislav Valkovič and Professor Karl Morten at the Oxford Centre for Clinical Magnetic Resonance Research, the study will compare muscle mitochondrial function in people with mild ME/CFS and healthy sedentary controls using non-invasive MRI and near-infrared spectroscopy (NIRS).
Researchers will examine whether people with ME/CFS show reduced mitochondrial function and, in a later Stage 2 subject to funding, whether these abnormalities become more pronounced during PEM.
The study focuses on calf-muscle energy metabolism, including phosphocreatine recovery after exercise, as a measure of oxidative energy production. Urine samples will be collected to try and replicate a related study from America, and blood samples will be used to support future research into metabolic, proteomic, and cellular abnormalities.
Stage 1 is recruiting 20 people with mild ME/CFS and 10 healthy sedentary controls, matched by age and gender. Participants will attend the John Radcliffe Hospital in Oxford for clinical assessment, MRI and NIRS exercise testing, sampling, questionnaires, and smart-watch monitoring. Compensation for time and travel will be offered, and ethical approval has been granted.
Any questions should be sent via email to Professor Valkovic: ladislav.valkovic@cardiov.ox.ac.uk
Read more: https://meassociation.org.uk/56m9
#MECFS #pwME #MyalgicE #RamsayResearchFund #Research #PEM
Research: Does poor oxygenation and a delay in muscle energy recovery contribute to fatigue and PEM in ME/CFS? Now Recruiting!
The ME Association is supporting Stage 1 of a University of Oxford study investigating whether impaired muscle oxygenation and delayed energy recovery contribute to fatigue and post-exertional malaise (PEM) in ME/CFS.
Led by Professor Ladislav Valkovič and Professor Karl Morten at the Oxford Centre for Clinical Magnetic Resonance Research, the study will compare muscle mitochondrial function in people with mild ME/CFS and healthy sedentary controls using non-invasive MRI and near-infrared spectroscopy (NIRS).
Researchers will examine whether people with ME/CFS show reduced mitochondrial function and, in a later Stage 2 subject to funding, whether these abnormalities become more pronounced during PEM.
The study focuses on calf-muscle energy metabolism, including phosphocreatine recovery after exercise, as a measure of oxidative energy production. Urine samples will be collected to try and replicate a related study from America, and blood samples will be used to support future research into metabolic, proteomic, and cellular abnormalities.
Stage 1 is recruiting 20 people with mild ME/CFS and 10 healthy sedentary controls, matched by age and gender. Participants will attend the John Radcliffe Hospital in Oxford for clinical assessment, MRI and NIRS exercise testing, sampling, questionnaires, and smart-watch monitoring. Compensation for time and travel will be offered, and ethical approval has been granted.
Any questions should be sent via email to Professor Valkovic: ladislav.valkovic@cardiov.ox.ac.uk
Read more: https://meassociation.org.uk/56m9
#MECFS #pwME #MyalgicE #RamsayResearchFund #Research #PEM