Trial Report Plasma cell targeting with the anti-CD38 antibody daratumumab in ME/CFS -a clinical pilot study, 2025, Fluge et al

[ryanc97]

Suggestive.

what is your take on the wording? does it imply the levels are similar or constant?

 

[EndME]

what is your take on the wording? does it imply the levels are similar or constant?

Don't know about the other antibodies but I'm pretty sure we've seen studies showing some fluctuating test results for the SARS-COV-2 antibodies including some decay over time. Given the duration of study an asymptomatic infection might also not be completely unlikely in a small subset of participants. So I would naively think "similar" levels is the best one could expect.

 

[Jaybee00]

Can’t antibodies persist in the blood for a while even if the cells that produced them are no longer there?

 

[Jonathan Edwards]

Can’t antibodies persist in the blood for a while even if the cells that produced them are no longer there?

They probably decay gradually with a half life of a month or so if their antigen is not around.

 

[ryanc97]

Best case scenario is that ME CFS LLPCs have more CD38 and are good targets that would explain why IGG drop between non responders and responders max difference was like 10-15%.