Press release: Inspiritol Effective In COVID-19, Long-COVID And ME/CFS Patients

Sly Saint

Sly Saint

Senior Member (Voting Rights)
Inspiritol, Inc. collaborating with Dr. Liisa Selin and Dr. Anna Gill at UMass Chan Medical School
Published: Oct. 25, 2021 at 8:51 AM CDT|Updated: 1 hour ago
FAIRFIELD, Conn., Oct. 25, 2021 /PRNewswire/ -- Inspiritol, Inc., a virtual pharmaceutical start-up filed a response with the FDA as part of their Investigational New Drug Application process for Inspiritol, a novel treatment for COVID-19, Long-COVID, and ME/CFS (Myalgic encephalomyelitis/chronic fatigue). Inspiritol is a nebulized inhaled multi-mechanism medication designed to treat the major symptoms of respiratory distress with anti-oxidant, anti-inflammatory, and broad spectrum anti-viral and anti-bacterial properties. Inspiritol is comprised of both endogenously produced and naturally occurring, well tolerated biochemicals co-developed by Dr. John P. Salerno, MD with a practice in New York City and George E. Hoag, Ph.D. Inspiritol, Inc. has several U.S. and foreign patent applications pending.

Since 2018, Dr. Salerno treated patients diagnosed with COPD, Asthma, COVID-19, Long-COVID, and ME/CFS with Inspiritol. Inspiritol Inc. is seeking approval from the FDA to conduct human clinical trials on patients with COVID-19, Long-COVID and ME/CFS. Dr. Salerno stated, "A hallmark of Inspiritol treated patients is a rapid increase of oxygen in their blood and decreases in fatigue and difficulty thinking, commonly referred to as 'brain fog'."

Dr. Liisa Selin, MD, Ph.D., Professor of Pathology and a specialist in infectious diseases and immunology with Anna Gil, Ph.D., both at UMass Chan Medical School have developed new methods to study biomarkers of chronic inflammatory diseases.

They discovered similarities in immune system responses of Long-COVID and ME/CFS patients, including CD8 T cell exhaustion, increased frequency of CD4+CD8+ T cells, and difficulty controlling persistent viral pathogens.

Dr. Selin said, "Our research findings could point to potential biomarkers, treatments and ways of tracking responses to therapies for Long-COVID and ME/CFS, methods that are immediately needed. Our research indicates that individuals with Long-COVID and ME/CFS have biological abnormalities, including; oxidative stress imbalances, systemic inflammation and neuroinflammation."

Working with Dr. Salerno's patients, Dr. Selin and Dr. Gil ran these same biomarker tests on two with Long-COVID and one with ME/CFS and reported, "We obtained dramatic improvement of these patients' symptoms associated with changes in their biomarkers without evidence of any significant side effects, including routine blood work, following continuous Inspiritol therapy from 2 to more than 5 months."
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https://www.wtvy.com/prnewswire/2021/10/25/inspiritol-effective-covid-19-long-covid-mecfs-patients/
 
Working with Dr. Salerno's patients, Dr. Selin and Dr. Gil ran these same biomarker tests on two with Long-COVID and one with ME/CFS and reported, "We obtained dramatic improvement of these patients' symptoms associated with changes in their biomarkers without evidence of any significant side effects, including routine blood work, following continuous Inspiritol therapy from 2 to more than 5 months."
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Does this really mean they only tried it on 3 patients or am I misunderstanding?
 
Braganca said:
Quite disappointed that two researchers with apparent promise have signed on to this. Feels like whenever I’m excited about an ME researcher, they then say or do something completely questionable…
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I know nothing off the drug itself, that stuff is beyond me. But testing it on 3 people and making statements on the back of that doesn't inspire confidence. Only statement that you could imo feasibly make is that it would need more studying if there was a positive result in those people.
 
<Sarcasm on>
When "Inspiritol" was being developed it was given a working name of "Snake Oil".
<Sarcasm off>

The name this stuff has been given is so dreadful I would laugh in the face of any doctor who recommended it for any purpose whatsoever. It also made me think of dreadful "inspirational" pictures like this one :

o_O:dead: :bag: :whistle: :borg:

iu
 
From the Inspiritol website:
Inspiritol® is an inhaled multi-mechanism treatment for respiratory distress and post viral illnesses comprised of endogenous and naturally occurring well tolerated biochemicals


Inspiritol is comprised of compounds have broad spectrum anti-inflammatory, antiviral, and antibacterial capabilities


Inspiritol works to re-establish dysregulated oxidant-antioxidant balance by interrupting free radical and cytokine storms central to respiratory diseases as well as viral and post viral illnesses
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Wow, quite the jackpot isn’t it? Using the big words to make believe that their stuff is working like magic. What can go wrong?

A website about a ‘drug’ that actually doesn’t say what’s in their compound.

That’s a very unfortunate collaboration for the promising researchers from Boston.
 
Feels like i'm playing the devil's advocate but there is at least something interesting about this. If i recall there was a study showing that oxygenated blood coming out of the lungs had inflammatory cytokines that previously weren't there. And there are also studies showing that most patients get ME/CFS after a respiratory infection. So maybe, the cause of the illness is actually in the lungs and nobody has looked at it yet. It doesn't necessarily have to do with oxygenation, it could be many other things. Even if this is just a cocktail of supplements, the fact that it's inhaled and not taken by mouth is interesting. Over the years i've seen patients try all sorts of drugs and supplements by mouth, injection, even fecal transplants but almost never inhaled stuff.

With all of this said, the way they are going about this surely doesn't inspire confidence... despite what the name of the drug might say.
 
Hubris said:
And there are also studies showing that most patients get ME/CFS after a respiratory infection
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Says who? Please add references. One of the most common viral onset is Epstein-Barr virus, or mononucleosis, and it isn’t a respiratory virus.

Hubris said:
Over the years i've seen patients try all sorts of drugs and supplements by mouth, injection, even fecal transplants but almost never inhaled stuff
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If the drug delivery was the problem, we’d already be on it. It is problematic that they are not saying what’s in their compound, and I am not sure i’d want to risk exposing my precious lung tissue with whatever droplet they want patients to breathe. I am hoping FDA sees clearly. Typically such compound is tested on healthy people first (phase 1)- i am made to believe that what they have invented may simply be water, oxygen, maybe ozone and a little oregano oil (my best bet, and please do not try that at home)
 
Milo said:
Says who? Please add references. One of the most common viral onset is Epstein-Barr virus, or mononucleosis, and it isn’t a respiratory virus.


If the drug delivery was the problem, we’d already be on it. It is problematic that they are not saying what’s in their compound, and I am not sure i’d want to risk exposing my precious lung tissue with whatever droplet they want patients to breathe. I am hoping FDA sees clearly. Typically such compound is tested on healthy people first (phase 1)- i am made to believe that what they have invented may simply be water, oxygen, maybe ozone and a little oregano oil (my best bet, and please do not try that at home)
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Sorry i don't remember which study it was, maybe someone else does.
I mean, we will know soon enough what's inside. I don't see how they can market, let alone publish a study on it without saying what's inside..
 
It sounds like some sort of nutrient and herb concoction. Who knows, maybe there's something in it that might help some people. I guess the good thing about this is that Doctors Sellin and Gill seem to be decent scientists who probably know how to run clinical trials, unlike a lot of people who just push 'nutriceuticals' for years for their own profit, with no proper research to back them.
 
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