Closed RECLAIM: Recovering From COVID-19 Lingering Symptoms Adaptive Integrative Medicine

[forestglip]

RECLAIM: Recovering From COVID-19 Lingering Symptoms Adaptive Integrative Medicine

Drug: Ibudilast
10mg pills, 2 pills twice per day
Other Names:

Drug: Pentoxifylline
400mg pill 3 times per day

Other: Placebo
Placebo matching ibudilast, 2 pills twice per day OR placebo matching pentoxifylline 1 pill 3 time per day.

Participants will be randomized initially to 1 of 3 arms, including placebo (control) and 2 interventions. Because this is an adaptive trial, arms can be dropped if found to be ineffective and new arms can be added.

Interventions will last for 2 months and participants will be followed for an additional 4 months (6 months total). Approximately 800-1000 patients with Long COVID will be recruited across Canada.

ClinicalTrials.gov

 

[forestglip]

@Jaybee00 let me know about this:

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- https://xcancel.com/mildTin/status/1936644648078074275

The Canadian Ibudilast & Pentoxyfilline trial - no improvement over placebo

More strikingly - look at that placebo graph. The amount of improvement, over just a period of 2 months. Patient selection is key for LC trials...

Discussion of trial starts at 36:25